Research News

A research group led by Associate Professor Chie Kojima and Professor Akikazu Matsumoto of Graduate School of Engineering, and by Professor Ikuo Fujii and Professor Ikuhiko Nakase of Graduate School of Science, published a paper entitled “Carboxy-terminal dendrimers with phenylalanine for a pH-sensitive delivery system into immune cells including T cells.” The paper is featured on the cover of the Journal of Materials Chemistry B.
This research successfully delivered dendrimer nanoparticles into T cells, by the surface modification of hydrophobic amino acid phenylalanine. The dendrimer showed pH-sensitive properties for delivery into cells, and are expected to advance immunotherapy treatments for cancer.

*Notes
Established in April 2022, Osaka Metropolitan University (OMU) is a new public general university formed by a merger between Osaka City University and Osaka Prefecture University.

Paper Information

Journal title: Journal of Materials Chemistry B
Paper title: Carboxy-terminal dendrimers with phenylalanine for a pH-sensitive delivery system into immune cells including T cells
DOI: 10.1039/D1TB01980E

Funding

This work was supported in part by Grants-in-Aid for Scientific Research (KAKENHI), Grant-in-Aid for Scientific Research on Innovative Areas, “Aquatic Functional Materials” (20H05232) (Project Leader: Professor Takashi Kato, the University of Tokyo).

Related information

A press release on this paper was published on January 26, 2022.
A Novel Nanoplatform for Delivering Drugs into Lymphocytes (OPU Website)

Media Contact

Department of Applied Chemistry, Graduate School of Engineering
Dr. Chie KOJIMA
E-mail kojima[at]chem.osakafu-u.ac.jp
*Please change [at] to @.