Research News

Building up new macrocyclic molecules using both dynamic covalent and coordination reactions

Combining dynamic covalent chemistry and coordination chemistry to synthesize new macrocyclic molecules

The molecule features both radical-based dynamic covalent bonds and coordinate bonds.

Credit: Daisuke Sakamaki, Osaka Metropolitan University

A research group led by Professor Hideki Fujiwara and Associate Professor Daisuke Sakamaki from the Graduate School of Science at Osaka Metropolitan University succeeded, for the first time, in synthesizing a new molecule using a novel combination of dynamic covalent chemistry, in which organic radicals couple and dissociate reversibly, and coordination chemistry, which binds radicals to metal ligands. The study shows that the two types of reactions work without inhibiting each other.

“This research was based on a very simple idea of combining two types of reactions,” stated Professor Sakamaki. “However, it was not clear if these reactions could coexist because they are so different in nature. Our results are expected to contribute to the development of new synthetic components for functional materials, such as sensing materials and porous materials.”

The study findings were published in Angewandte Chemie International Edition.

Funding

This work was supported by a Grant-in-Aid for Scientific Research (17H04874, 18K05264, 20H02726) from the Japan Society for the Promotion of Science (JSPS), a Grant-in-Aid for Transformative Research Areas (A) “Condensed Conjugation” (JSPS KAKENHI Grant Number JP20H05866) from MEXT, and the Ogasawara Toshiaki Memorial Foundation.

Paper Information

Journal: Angewandte Chemie International Edition
Title: A Dicyanomethyl Radical Conjugated with a Pyridylamino Group: Combining Radical-based Dynamic Covalent Chemistry and Coordination Chemistry
DOI: 10.1002/anie.202302498
Author: Hiroki Hasegawa, Daisuke Sakamaki, Hideki Fujiwara
Publication date: 4 May 2023

https://doi.org/10.1002/anie.202302498

Contact

Graduate School of Science
Daisuke SAKAMAKI
E-mail: sakamaki[at]omu.ac.jp
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