Research News

Conversely, role in controlling cell proliferation might lead to novel tumor therapies in humans

How a single gene can make a difference

Zebrafish embryos with a normally formed notochord and an abnormal, severely shortened notochord.

Credit: Osaka Metropolitan University

Can a single protein-encoding gene determine whether a vertebrate embryo develops normally? Yes, according to Osaka Metropolitan University researchers, who found that suppression of Pcdh8 is essential for the notochord to elongate properly in zebrafish.

Graduate School of Medicine Dr. Masatake Kai and Professor Makoto Kondo focused on this paraxial protocadherin (PAPC), which is excluded when dividing cells migrate and form the notochord in the embryo.

In the experiments with zebrafish embryo, when this PAPC is not excluded, the cells do not move to the appropriate location, preventing the notochord from elongating to its proper length. The researchers suggest that the role this gene plays in controlling cell proliferation when expressed might lead to novel tumor therapies in humans.

“In this case, the results were obtained using zebrafish, but it is possible that a similar mechanism may also be at work in mammals,” Professor Kondo stated. “We hope to make more progress in understanding the complex mechanisms that give rise to the forms of living things.”

The findings were published in Scientific Reports.

Funding

This work was supported by JSPS KAKENHI grant numbers JP22K06815 (M Kai) and JP22K11498 (M Kondo) and AMED (Japan Agency for Medical Research and Development) grant numbers JP21wm0525026 (M Kondo) and JP20lm02003007 (M Kondo).

Paper information

Journal: Scientific Reports
Title:  Suppression of Pcdh8/paraxial protocadherin is required for efficient neighbor exchange in morphogenetic cell movement during zebrafish notochord formation
DOI: 10.1038/s41598-024-76762-7
Authors:  Masatake Kai, Makoto Kondo
Published: 28 October 2024
URL: https://doi.org/10.1038/s41598-024-76762-7

Contact

Graduate School of Medicine
Masatake Kai
Email: kai[at]omu.ac.jp

Makoto Kondo
Email: mkondo[at]omu.ac.jp

*Please change [at] to @.