Research Results
Aug 4, 2020
- Press Release
- Joint Research Paper
A press release on the results of the joint research between Prof. Yutaka Amao and Asst. Prof. Akimitsu Miyaji (Tokyo Institute of Technology) has been issued
How Biologen Cation Radicals Improve the Carbon Dioxide Reduction Catalytic Capacity of Formatic Acid Dehydrogenase
Key points of this study
- In addition to the enzyme kinetics, which examines the enzyme kinetics, in the process of converting carbon dioxide into formic acid, an organic molecule, in the process of converting carbon dioxide into the organic molecule formic acid in the artificial photosynthesis system, we analyzed how the cationic radical*1 of methylbiogen, a coenzyme that is effective in activating formic acid dehydrogenase, is involved in improving enzyme activity based on experimental data, and the mechanism is clarified in detail.
- It is an important guideline for the design and development of coenzymes that efficiently convert carbon dioxide into organic molecules for the realization of artificial photosynthetic systems.
*1 Cation radicals…Those that have a positive charge and also have unpaired electrons.
Summary
Professor Yutaka Amao (Research Center for Artificial Photosynthesis, Osaka City University) and Assistant Professor Akimitsu Miyaji (Department of Applied Chemistry at the School of Materials and Chemical Technology, Tokyo Institute of Technology) have clarified the electron supply mechanism of methylbiogen cationic radicals in the process of reducing carbon dioxide to formic acid catalyzed by formic acid dehydrogenase in an artificial photosynthesis system.
In the development of catalysts, which are being promoted as an important element technology for the creation of artificial photosynthetic systems that convert carbon dioxide into organic molecules using solar energy, the essential interaction of how the cationic radical (MV.+) of methylbiogen, a coenzyme, reduces carbon dioxide to formic acid in formic acid dehydrogenase (FDH) has not been clarified.
In addition to several reaction models based on enzymatic kinetics, the mechanism of electron supply by MV.+ was clarified from both experimental and theoretical studies by determining the binding mode of MV.+ in FDH based on theoretical chemical calculations and the electronic state of MV.+ by density functional theory (DFT).
The results of this research were published in Physical Chemistry Chemical Physics (PCCP), a journal of physical chemistry published by the Royal Society of Chemistry (RSC).
Financial Information
The results of this research were obtained through the Joint Usage/Joint Research Project of the Center for Artificial Photosynthesis, Osaka City University, the Grants-in-Aid for International Joint Research (B), and the Grants-in-Aid for Scientific Research on Innovative Areas.
Publication Information
| Publications: | Physical Chemistry Chemical Physics (PCCP)(Royal Society of Chemistry発刊) |
|---|---|
| Title of Paper: | How does methylviologen cation radical supply two electrons to the formate dehydrogenase in the catalytic reduction process of CO2 to formate? |
| Author: | MIYAJI, Akimitsu, AMAO, Yutaka |
| URL: | https://pubs.rsc.org/en/content/articlehtml/2020/cp/d0cp02665d |