研究業績

2024年

Merlin/NF2 regulates SLC7A11/xCT expression and cell viability under glucose deprivation at high cell density in glioblastoma cells. 　
Yamaguchi I., Katoh H.
J. Biochem. 175, 313–322 (2024)

Investigating the Protective Effects of a Citrus Flavonoid on the Retardation Morphogenesis of the Oligodendroglia-like Cell Line by Rnd2 knockdown. 　
Fukatsu S., Miyamoto Y., Oka Y., Ishibashi M., Shirai R., Ishida Y., Endo S., Katoh H., Yamauchi J. 
Neurol. Int. 16, 33-61  (2024)

2023年

JCI Insight  24, e165469 (2023)

がん細胞のシスチン代謝に対する細胞外環境の影響．

山口一樹、　加藤裕教．
生化学　Vol. 95 792-796 (2023)

2022年

Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosis. 　
Hayashima K., Katoh H.
J. Biol. Chem. 298, 101703 (2022)

Filamin A forms a complex with EphA2 and regulates EphA2 serine 897 phosphorylation and glioblastoma cell proliferation.
Tamura Y., Nakamizo Y., Watanabe Y., Kimura I., Katoh, H.
Biochem. Biophys. Res. Commun. 597, 64-70 (2022)

2021年

Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells.
Hayashima K., Kimura I., Katoh H.
Biochem. Biophys. Res. Commun. 539, 56-63 (2021)

Epidermal growth factor promotes glioblastoma cell death under glucose deprivation via upregulation of xCT. (SLC7A11).
Yamamoto M., Teramoto K., Katoh H.
Cell. Signal. 78, 109874 (2021)

Rnd2 differentially regulates oligodendrocyte myelination at different developmental periods.
Miyamoto Y., Torii T., Terao M., Takeda S., Tanoue A., Katoh H., Yamauchi J.
Mol. Biol. Cell 32, 769-787 (2021)

2020年

High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11).
Yamaguchi I., Yoshimura S.H., Katoh H.
J. Biol. Chem. 295, 6936-6945 (2020)

2019年

The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions.
Teramoto K., Katoh H.
Cell. Signal. 62, 109329 (2019)

EphA3 is up-regulated by epidermal growth factor and promotes formation of glioblastoma cell aggregates.
Toyama M., Hamaoka Y., Katoh H.
Biochem. Biophys. Res. Commun. 508, 715-721 (2019)

RasGRF1 mediates brain-derived neurotrophic factor-induced axonal growth in primary cultured cortical neurons. Umeda K., Negishi M., Katoh H.
Biochem. Biophys. Rep. 17, 56-64 (2019)

Opposite effects of cystine/glutamate antiporter xCT inhibitors on cancer progression.
Katoh H.
Nihon Yakurigaku Zasshi. 153, 88 (2019)

2018年

Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation.
Hamaoka Y., Negishi M., Katoh H.
Biochem. Biophys. Res. Commun. 499, 920-926 (2018)

2017年

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation.
Goji T., Takahara K., Negishi M., Katoh H.
J. Biol. Chem. 292, 19721-19732 (2017)

Tyrosine phosphorylation of SGEF regulates RhoG activity and cell migration.
Okuyama Y., Umeda K., Negishi M., Katoh H.
PLoS One 11, e0159617 (2016)

2015年

Eph/ephrin reverse signalling induces axonal retraction through RhoA/ROCK pathway.
Takeuchi S., Katoh H., Negishi M.
J. Biochem. 158, 245-52 (2015)

HGF-induced serine 897 phosphorylation of EphA2 regulates epithelial morphogenesis of MDCK cells in 3D culture. Harada K., Negishi M., Katoh H.
J. Cell Sci. 128, 1912-1921 (2015)

2014年

EphB6 promotes anoikis by modulating EphA2 signaling.
Akada M., Harada K., Negishi M., Katoh H.
Cell. Signal. 26, 2879-2884 (2014)

Dock4 forms a complex with SH3YL1 and regulates cancer cell migration.
Kobayashi M., Harada K., Negishi M., Katoh H.
Cell. Signal. 26, 1082-1088 (2014)

2013年

Ephexin4-mediated promotion of cell migration and anoikis resistance is regulated by serine 897 phosphorylation of EphA2.
Kawai H., Kobayashi M., Hiramoto-Yamaki N., Harada K., Negishi M., Katoh H.
FEBS Open Bio 3, 78-82 (2013)

Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.
Ueda S., Negishi M., Katoh H.
Mol. Biol. Cell 24, 1602-1613 (2013)

2012年

The RhoG signaling pathway.
Katoh H.
Seikagaku 84, 539-550 (2012)

2011年

The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons.
Wakita Y., Kakimoto T., Katoh H., Negishi M.
J. Biol. Chem. 286, 32672-32683 (2011)

Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase.
Harada K., Hiramoto-Yamaki N., Negishi M., Katoh H.
Exp. Cell Res. 317, 1701-1713 (2011)

2010年

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.
Hiramoto-Yamaki N., Takeuchi S., Ueda S., Harada K., Fujimoto S., Negishi M., Katoh H.
J. Cell Biol.190, 461-477 (2010)

Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons.
Oinuma I., Ito Y., Katoh H., Negishi M.
J. Biol. Chem. 285, 28200-28209 (2010)

2009年

RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex.
Fujimoto S., Negishi M., Katoh H.
Mol. Biol. Cell 20, 4941-4950 (2009)

Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons.
Kuramoto K., Negishi M., Katoh H.
J. Neurosci. Res. 87, 1794-1805 (2009)

β2-chimaerin binds to EphA receptors and regulates cell migration.
Takeuchi S., Yamaki N., Iwasato T., Negishi M., Katoh H.
FEBS Lett.583, 1237-1242 (2009)

Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1.
Uesugi K., Oinuma I., Katoh H., Negishi M.
J. Biol. Chem.284, 6743-6751 (2009)

2008年

Lysophosphatidic acid and thrombin receptors require both Gα12 and Gα13 to regulate axonal morphology in hippocampal neurons.
Yamazaki J., Katoh H., Negishi M.
Biol. Pharm. Bull.31, 2216-2222 (2008)

Dock4 regulates dendritic development in hippocampal neurons.
Ueda S., Fujimoto S., Hiramoto K., Negishi M., Katoh H.
J. Neurosci. Res. 86, 3052-3061 (2008)

2007年

RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism.
Yamaki N., Negishi M., Katoh H.
Exp. Cell Res. 313, 2821-2832 (2007)

R-Ras controls axon specification upstream of glycogen synthase kinase-3beta through integrin-linked kinase.
Oinuma, I., Katoh H., Negishi M.
J. Biol. Chem. 282, 303-318 (2007)

Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.
Iwasato T., Katoh H., Nishimar, H., Ishikawa Y., Inoue H., Saito Y.M., Ando R., Iwama M., Takahashi R., Negishi M., Itohara S. Cell 130, 742-753 (2007)

Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis.
Nakase I., Tadokoro A., Kawabata N., Takeuchi T., Katoh H., Hiramoto K., Negishi M., Nomizu M., Sugiura Y., Futaki S. Biochemistry 46, 492-501 (2007)

2006年

Dock4 is regulated by RhoG and promotes Rac-dependent cell migration.
Hiramoto K., Negishi M., Katoh H.
Exp. Cell Res. 312, 4205-4216 (2006)

Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination. Kakimoto T., Katoh H., Negishi M.
J. Biol. Chem. 281, 29042-29053 (2006)

Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse.
Ito Y., Oinuma I., Katoh H., Kaibuchi K., Negishi M.
EMBO Rep. 7, 704-709 (2006)

GEFs and gaps of Rho family GTPases.
Negishi M., Katoh H.
Tanpakushitsu Kakusan Koso 51, 693-698 (2006)

Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating β1 integrin activity. Oinuma I., Katoh H., Negishi M.
J. Cell Biol. 173, 601-613 (2006)

Small GTPase Rnd1 is involved in neuronal activity-dependent dendritic development in hippocampal neurons. Ishikawa Y., Katoh H., Negishi M.
Neurosci. Lett. 400, 218-223 (2006)

Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.

Activation of Rac1 by RhoG regulates cell migration.
Katoh H., Hiramoto K., Negishi M.
J. Cell Sci. 119, 56-65 (2006)

In vivo function of Rnd2 in the development of neocortical pyramidal neurons.
Nakamura K., Yamashita Y., Tamamaki N., Katoh H., Kaneko T., Negishi M.
Neurosci. Res. 54, 149-153 (2006)

2005年

R-ras as a key player for signaling pathway of plexins.
Negishi M., Oinuma I., Katoh H.
Mol. Neurobiol. 32, 217-222 (2005)

Socius, a novel binding partner of Gα12/13, promotes the Gα12-induced RhoA activation.
Tateiwa K., Katoh H., Negishi M.
Biochem. Biophys. Res. Commun. 337, 615-620 (2005)

Rho family GTPases and dendrite plasticity.
Negishi M., Katoh H.
Neuroscientist 11, 187-191 (2005)

Two G12 family G proteins, Gα12 and Gα13, show different subcellular localization.
Yamazaki J., Katoh H., Yamaguchi Y., Negishi M.
Biochem. Biophys. Res. Commun. 332, 782-786 (2005)

Plexins: axon guidance and signal transduction.
Negishi M., Oinuma I., Katoh H.
Cell Mol. Life Sci. 62, 1363-1371 (2005)

Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.
Harada A., Katoh H., Negishi M.
J. Biol. Chem.280, 18418-18424 (2005)

Signaling mechanisms of axon guidance factor, semaphorins.
Negishi M., Katoh H.
Tanpakushitsu Kakusan Koso 50, 141-147 (2005)

2004年

Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons.
Oinuma I., Katoh H., Negishi M.
J. Neurosci. 24, 11473-11480 (2004)

The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras.
Oinuma I., Ishikawa Y., Katoh H., Negishi M.
Science 305, 862-865 (2004)

Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching.
Kakimoto T., Katoh H., Negishi M.
J. Biol. Chem. 279, 14104-14110 (2004)

PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells. Sakai Y., Hashimoto H., Shintani N., Katoh H., Negishi M., Kawaguchi C., Kasai A., Baba A.
Brain Res. Mol. Brain Res. 123, 18-26 (2004)

2003年

A role of Rnd1 GTPase in dendritic spine formation in hippocampal neurons.
Ishikawa Y., Katoh H., Negishi M.
J. Neurosci. 23, 11065-11072 (2003)

RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
Katoh H., Negishi M.
Nature 424, 461-464 (2003)

Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells.

Yamaguchi Y., Katoh H., Negishi M.
J. Biol. Chem. 278, 14936-14939 (2003)

2002年

Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching.
Fujita H., Katoh H., Ishikawa Y., Mori K., Negishi M.
J. Biol. Chem. 277, 45428-45434 (2002)

Developmental changes in expression of small GTPase RhoG mRNA in the rat brain.
Ishikawa Y., Katoh H., Nakamura K., Mori K., Negishi M.
Brain Res. Mol. Brain Res. 106, 145-150 (2002)

Gα12 and Gα13 interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity.
Yamaguchi Y., Katoh H., Mori K., Negishi M.
Curr. Biol. 12, 1353-1358 (2002)

Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2.
Tanaka H., Fujita H., Katoh H., Mori K., Negishi M.
Biochem. J. 365, 349-353 (2002)

The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area.
Nakamura K., Matsumura K., Kaneko T., Kobayashi S., Katoh H., Negishi M.
J. Neurosci. 22, 4600-4610 (2002)

Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.
Katoh H., Harada A, Mori K, Negishi M.
Mol. Cell. Biol. 22, 2952-2964 (2002)

Rho family GTPases as key regulators for neuronal network formation.
Negishi M., Katoh H.
J. Biochem. 132, 157-166 (2002)

2001年

Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain.
Nakamura K., Li Y.Q., Kaneko T., Katoh H., Negishi M.
Neuroscience 103, 763-775 (2001)

Differential responses to nerve growth factor and epidermal growth factor in neurite outgrowth of PC12 cells are determined by Rac1 activation systems.
Yasui H., Katoh H., Yamaguchi Y., Aoki J., Fujita H., Mori K., Negishi M.
J. Biol. Chem. 276, 15298-15305 (2001)

RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway. Yamaguchi Y., Katoh H., Yasui H., Mori K., Negishi M.
J. Biol. Chem. 276, 18977-18983 (2001)

2000年

Molecular decipherment of Rho effector pathways regulating tight-junction permeability.
Fujita H., Katoh H., Hasegawa H., Yasui H., Aoki J., Yamaguchi Y., Negishi M.
Biochem. J. 346, 617-622 (2000)

Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system.
Nakamura K., Kaneko T., Yamashita Y., Hasegawa H., Katoh H., Negishi M.
J. Comp. Neurol. 421, 543-569 (2000)

Gα12 and Gα13 inhibit Ca2+-dependent exocytosis through Rho/Rho-associated kinase-dependent pathway. Yamaguchi Y., Katoh H., Yasui H., Aoki J., Nakamura K., Negishi M.
J. Neurochem. 75, 708-717 (2000)

Different membrane targeting of prostaglandin EP3 receptor isoforms dependent on their carboxy-terminal tail structures.
Hasegawa H., Katoh H., Yamaguchi Y., Nakamura K., Futakawa S., Negishi M.
FEBS Lett. 473, 76-80 (2000)

Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells.
Katoh H., Yasui H., Yamaguchi Y., Aoki J., Fujita H., Mori K., Negishi M.
Mol. Cell. Biol. 20, 7378-73787 (2000)

Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin.
Hasegawa H., Katoh H., Fujita H., Mori K., Negishi M.
Biochem. Biophys. Res. Commun. 276, 350-354 (2000)

1999年

Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus.
Nakamura K., Kaneko T., Yamashita Y., Hasegawa H., Katoh H., Ichikawa A., Negishi M.
Neurosci. Lett. 260, 117-120 (1999)

The key amino acid residue of prostaglandin EP3 receptor for governing G protein association and activation steps. Satoh S., Chang Cs., Katoh H., Hasegawa H., Nakamura K., Aoki J., Fujita H., Ichikawa A., Negishi M.
Biochem. Biophys. Res. Commun. 255, 164-168 (1999)

Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases.
Aoki J., Katoh H., Yasui H., Yamaguchi Y., Nakamura K., Hasegawa H., Ichikawa A., Negishi M.
Biochem. J. 340, 365-369 (1999)

Opposite regulation of transepithelial electrical resistance and paracellular permeability by Rho in Madin-Darby canine kidney cells. 
Hasegawa H., Fujita H., Katoh H., Aoki J., Nakamura K., Ichikawa A., Negishi M.
J. Biol. Chem. 274, 20982-20988 (1999)

1998年

Constitutively active Gα12, Gα13, and Gαq induce Rho-dependent neurite retraction through different signaling pathways.

Katoh H., Aoki J., Yamaguchi Y., Kitano Y., Ichikawa A., Negishi M.
J. Biol. Chem. 273, 28700-28707 (1998)

Inhibition of dopamine release by prostaglandin EP3 receptor via pertussis toxin-sensitive and -insensitive pathways in PC12 cells.
Nakamura K., Katoh H., Ichikawa A., Negishi M.
J. Neurochem. 71, 646-652 (1998)

p160 RhoA-binding kinase ROKα induces neurite retraction.
Katoh H., Aoki J., Ichikawa A., Negishi M.
J. Biol. Chem. 273, 2489-2492 (1998)