研究内容

晶析分野

　私たちの生活に不可欠な医薬品、食品、そして実験に使われる化学薬品などの多くは粉末として流通しています。そして、その多くが結晶です。一口に結晶といってもすべての結晶が同じ形や構造をしているのではありません。結晶構造が異なれば溶解度や溶解速度などが異なるため、医薬品においては効き目にも影響を及ぼす恐れがあります。このような分野の基盤技術を発展させるため、工業的に結晶を製造するための研究、すなわち晶析の研究を行っています。

バイオマス分野

　再生可能エネルギーの有効活用を図るために、木質系バイオマスの水熱分解に関する研究を行っています。木質系バイオマスに含まれるセルロースやヘミセルロースはバイオエタノールの原料となりますが、もう一つの成分であるリグニンの利用法は確立されていません。リグニンは、石油以来の化学原料の代替品となる可能性があるので、効率の良い分解法について研究を行っています。

Efficient optical resolution of DL-glutamate by combining enzymatic racemization
Koichi Igarashi, Tomono Fujimura, DOI10.1080/00219592.2023.2197012, 2023

Polymorphic crystallization design to prevent the degradation of the β-lactam structure of a carbapenem, Shinji Matsuura, Koichi Igarashi, Masayuki Azuma and Hiroshi Ooshima, Crystals, 11(8), 2021

Simultaneous Control of Crystal Habit and Particle Size of Ecabet Sodium Hydrate with Rapid Cooling Crystallization and Temperature Cycling, Kishida Muneki, Igarashi Koichi, Azuma Masayuki, Ooshima Hiroshi, JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 52(5), 455-464, 2019

Pharmaceutical Microcrystal Formation by Supersaturation Control with an Electrolyte 査読
Muneki Kishida, Koichi Igarashi, Masayuki Azuma, Hiroshi Ooshima
Journal of Chemical Engineering of Japan, 51(7), 1-6, 2018

Behavior of t-butoxycarbonyl-L-asparagine (Boc-Asn) on the initial stage of crystallization,
Koichi Igarashi*, Masako Aoki, Yoshiko Masuda, Masayuki Azuma and Hiroshi Ooshima, Journal of Chemical Engineering of Japan,50(1),111-115, 2018

Localized Solvent Effects on the Crystal Habit of tert-Butoxycarbonyl-L-asparagine (BocASN),
Masaru Hirano, Koichi Igarashi, Hiroshi Ooshima, Journal of Chemical Engineering of Japan,50,207-212, 2017

Cooling crystallization Using a mL-Scale Continuous Crystallizer Equipped with a High Speed Agitator for Production of Uniform Small Crystals,
Koichi Igarashi, Hiroshi Ooshima, Journal of Chemical Engineering of Japan,49, 805-808, 2016

Crystallization Behavior of Ibuprofen under the Microwave Irradiation, Koichi Igarashi, Sumito Kihara and Hiroshi Ooshima, Journal of Chemical Engineering of Japan, 46(12), 797-801, 2013

Structure of supersaturated solution and crystal nucleation induced by diffusion, Hiroshi Ooshima, Koichi Igarashi, Hideo Iwasa, Ren Yamamoto, Journal of Crystal Growth,373, 2-6, 2013

Repeated Cooling Crystallization for Production of Microcrystals with a Narrow Size Distribution, Zhongyuan Xing, Koichi Igarashi, Ayumi Morioka and Hiroshi Ooshima, Journal of Chemical Engineering of Japan,45(10), 811-815, 2012

Control of Crystal Size Distribution Using a mL-Scale Continuous Crystallizer Equipped with a High Speed Agitator, Koichi Igarashi, Yasuhiro Yamanaka, Masayuki Azuma and Hiroshi Ooshima, Journal of Chemical Engineering of Japan,45（１）, 28-33, 2012

Relationship between Crystal Polymorphism and Solution Structure of an Imidazopyridine Derivative Developed as a Drug Substance for Osteoporosis, Masaru Hirano, Koichi Igarashi, Kouji Machiya, Rui Tamura, Hiroto Tue and Hiroshi Ooshima, Journal of Chemical Engineering of Japan,42(3), 204-211, 2009

Synthesis and degradation of acyl peptide using enzyme from Pseudomonas aeruginosa, Islam NN., Igarashi K., Tachibana T., Ooshima H., Azuma M., Journal of Bioscience and Bioengineering, 105(3), 282-287, 2008

Growth mechanism of the Calcium Carbonate Tubes on a Cation-exchange Membrane, K. Igarashi, M. Takiguchi and H. Ooshima, Journal of the Ceramic Society of Japan, 116(1), 111-114, 2008

Saccharomyces cerevisiae mutant displaying beta-glucans on cell surface, Sakai Y., Azuma M., Takada Y., Umeyama T., Kaneko A., Fujita T., Igarashi K., Ooshima H., Journal of Bioscience and Bioengineering,103(2), 161-166, 2007

Purification and Characterization of Enzyme Responsible for N-Myristoylation of Octapeptide in Aqueous Solution without ATP and Coenzyme A from Pseudomonas aeruginosa, Takahiro Jyomoto, Masayuki Azuma, Nazneen Naher Islam, Ryo Fujinami, Toshifumi Takao, Takayuki Ogawa, Masaki Tabuchi, Koichi Igarashi, Jyoji Kato and Hiroshi Ooshima, Journal of Bioscience and Bioengineering,102(3), 193-197, 2006

Flowerlike Agglomerates of Calcium Carbonate Crystals Formed on an Eggshell Membrane, M. Takiguchi, K. Igarashi, M. Azuma, and H. Ooshima, Crystal Growth & Design, 6(12), 2754-2757, 2006

Studies on the hydration of Aerosol OT and the formation of reversed micelles in decane by a calorimetry and ab initio calculation, K. Sameshima, R. Tanaka, K. Igarashi, H. Ooshima, J. Chem. Thermodynamics,38, 662-671, 2006]

Relationship between Cell Morphology and Intracellular Potassium Concentration in Candida albicans, H. Watanabe, M. Azuma, K. Igarashi, H. Ooshima, J. Antibiot., 59(5), 281-287, 2006

Tubular Structure Agglomerates of Calcium Carbonate Crystals Formed on a Cation-Exchange Membrane, M. Takiguchi, K. Igarashi, M. Azuma, and H. Ooshima, Crystal Growth & Design,6(7), 1611-1614, 2006

Crystallization of β-Sitosterol Using a Water-Immiscible Solvent Hexane, Hideo Kawachi, Rika Tanaka, Masaru Hirano, Koichi Igarashi and Hiroshi Ooshima, Journal of Chemical Engineering of Japan, 39, 869-875, 2006

Manipulation of morphological transition in Saccharomyces cerevisiae mutant J19, Maneesri J, Azuma M, Igarashi K, Sugihara A, Ooshima H, Biochemical Engineering Journal,27, 72-76, 2005

Deletion of MCD4 involved in glycosylphosphatidylinositol (GPI) anchor synthesis leads to an increase in beta-1,6-glucan level and a decrease in GPI-anchored protein and mannan levels in the cell wall of Saccharomyces cerevisiae, Maneesri J, Azuma M, Sakai Y, Igarashi K, Matsumoto T, Fukuda H, Kondo A, Ooshima H, Journal of Bioscience and Bioengineering,99, 354-360, 2005

Valinomycin Affects the Morphology of Candida albicans, H. Watanabe, M. Azuma, K. Igarashi, H. Ooshima, J. Antibiot.,58(12), 753-758, 2005

The Effects of Impurities on Crystallization of Polymorphs of a Drug Substance AE1-923, Masaki Okamoto, Masaya Hamano, Koichi Igarashi and Hiroshi Ooshima, Journal of Chemical Engineering of Japan,37(10), 1224-1231, 2004

Effects of a solute analogue p-acetoacetanisidide on the crystallization of p-acetanisidide , Saito A, Igarashi K, Azuma M, Ooshima H, Journal of Chemical Engineering of Japan,36, 953-958, 2003

Control of Polymorphs on the Crystallization of Glycine Using WWDJ Batch Crystallizer, K. Igarashi, Y. Sasaki, M. Azuma, H. Noda, H. Ooshima, Eng. Life. Sci.,3, 159-163, 2003

Characterization of a Saccharomyces cerevisiae Mutant with Pseudohyphae and Cloning of a Gene Complementing the Mutation, Jaruwan Maneesri, Masayuki Azuma, Satoshi Torii, Koichi Igarashi, Hiroshi Ooshima, Biosci. Biotechnol. Biochem.,67(3), 517-524, 2003

Production of Large Crystals of Glycine with a Narrow Size Distribution Using WWDJ-Batch Crystallizer, H. Ooshima, K. Igarashi, Y. Sasaki, M. Azuma, H. Noda, Chemical Engineering Transactions, 1, 981-986, 2002

Control of Polymorphs on the Crystallization of Glycine Using WWDJ Batch Crystallizer, K. Igarashi, Y. Sasaki, M. Azuma, H. Noda, H. Ooshima, Chemical Engineering Transactions, 1, 683-688, 2002

Aggregation of p-Acetanisidide Molecules in the Under and Super-saturated Solution and Its Effect on Crystallization, A. Saito, K. Igarashi, M. Azuma, H. Ooshima, Journal of Chemical Engineering of Japan,35, 1133-1139, 2002

Dissolution kinetics of crystals in suspension and its application to L-aspartic acid crystals, Gu Shan, Koichi Igarashi, Hiroshi Ooshima, Chemical Engineering Journal, 88, 53-58, 2002

Production of large crystals with a narrow crystal size distribution by a novel WWDJ batch crystallizer, Gu Shan, Koichi Igarashi, Hideo Noda, Hiroshi Ooshima, Chemical Engineering Journal,85, 161-167, 2002

Control of solvent-mediated transformation of crystal polymorphs using a newly developed batch crystallizer (WWDJ-crystallizer), Gu Shan, Koichi Igarashi, Hideo Noda, Hiroshi Ooshima, Chemical Engineering Journal, 85, 169-176, 2002

Light intensity distribution in the externally illuminated cylindrical photo-bioreactor and its application to hydrogen production by Rhodobacter capslatus, Tomohisa Katsuda, Takeshi Arimoto, Koichi Igarashi, Masayuki Azuma, Jyoji Kato, Susumu Takakuwa, Hiroshi Ooshima, Biochemical Engineering Journal, 5, 157-164, 2000

Removal of Cadmium Ion by the Pohlia flexuosa, M. Azuma, A. Oobayashi, M. Kondoh, C. Kawasaki, K. Igarashi, J. Kato, H. Ooshima, Bioseparation Engineering, -, 175-180, 2000

The initial stage of crystallization of lysozyme: a differential scanning calorimetric (DSC) study, Koichi Igarashi, Masayuki Azuma, Jyoji Kato, Hiroshi Ooshima, Journal of Crystal Growth,204, 191-200, 1999

Mechanism of Crystal Growth of Protein: Differential Scanning Calorimetry of Thermolysin Crystal Suspension, H. Ooshima, S. Urabe, K. Igarashi, M. Azuma, J. Kato, ACS Symposium series,667, 18-27, 1997