業績 Publications

Publications

(2025)

Establishment of feline embryonic stem cells from the inner cell mass of blastocysts produced in vitro.
Regenerative Therapy 28:63-72, 2025. https://doi.org/10.1016/j.reth.2024.11.010

Myelin lesion in the aspartoacylase (Aspa) knockout rat, an animal model for Canavan disease.
Exp Anim 73(3):347-356, 2024. https://doi.org/10.1538/expanim.23-0089

Nishiyama K, Horikoshi J, Maehara T, Tanaka M, Tanida T, Kawada K, Takeshita S, Ono N, Izawa T, Kuwamura M, Azuma Y-T
Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid.
J Pharmacol Sci 155(3):94-100, 2024. https://doi.org/10.1016/j.jphs.2024.04.003

Sakai H, Kamuro H, Tokunoh N, Izawa T, Tamiya S, Yamamoto A, Tanaka S, Okuzaki D, Ono C, Matsuura Y, Okada Y, Yoshioka Y, Fujio Y, Obana M
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice.
Am J Physiol Renal Physiol 326(6):F931-F941, 2024. https://doi.org/10.1152/ajprenal.00011.2024

Inai Y, Izawa T, Kamei T, Fujiwara S, Tanaka M, Yamate J, Kuwamura M
Difference in the mechanism of iron overload-enhanced acute hepatotoxicity induced by thioacetamide and carbon tetrachloride in rats.
Toxicol Pathol 52(1):55-66, 2024. https://doi.org/10.1177/01926233241235623

Tanaka M, Fujikawa R, Sekiguchi T, Hernandez J, Johnson OT, Tanaka D, Kumafuji K, Serikawa T, Hoang Trung H, Hattori K, Mashimo T, Kuwamura M, Gestwicki JE and Kuramoto T
A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats.
Front Neurosci 18:1263724, 2024. https://www.frontiersin.org/articles/10.3389/fnins.2024.1263724/abstract

Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Fujita T, Kuwamura M, Azuma YT
Functional role of IL-19 in a mouse model of L-arginine-induced pancreatitis and related lung injury.
Exp Anim 73(2):175-185, 2024. https://doi.org/10.1538/expanim.23-0094

Murakami T, Kobayashi N, Iwaide S, Itoh Y, Hisada M, Izawa T, Kuwamura M
Identification of calcitonin receptor-stimulating peptide 1-derived amyloid in a feline C-cell carcinoma.
Amyloid 31(2):142-144, 2024. https://doi.org/10.1080/13506129.2023.2282361

Tsukamoto M , Kimura K , Yoshida T , Tanaka M ,  Kuwamura M , AyabeT , Ishihara G , Watanabe K , Okada M , IijimaM , Nakanishi M , Akutsu H , Sugiura K , Hatoya S 
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors.
Stem Cell Reports 19(1):141-157, 2024. https://doi.org/10.1016/j.stemcr.2023.11.010

(2023)

Noguchi S, Toyota K, Ozaki M, Wada Y, Takami Y, Tanaka M, Kuwamura M, Shimada T
Successful management of nasopharyngitis caused by Schizophyllum commune in a captive cheetah (Acinonyx jubatus).
J Vet Med Sci 85(10):1074-1076, 2023. https://doi.org/10.1292/jvms.23-0273

Takami Y, Tanaka M*, Morita M, Maruno T, Anai N, Sudo T, Kezuka C, Izawa T, Yamate J, Kuwamura M
Pleural mesothelioma in a California sea lion (Zalophus californianus).
J Vet Med Sci 85(9):1030-1033, 2023. https://doi.org/10.1292/jvms.22-0457

Watanabe S, Takagi A, Yuba E, Kojima C, Dei N, Matsumoto A, Tanikawa J, Kawamura T, De Silva NH, Izawa T, Akazawa T, Kanegi R, Hatoya S, Inaba T, Sugiura K
In vivo transfection of cytokine genes into tumor cells using a synthetic vehicle promotes antitumor immune responses in a visceral tumor model.
FASEB J 37(11):e23228, 2023. https://doi.org/10.1096/fj.202202036R

Pervin M, Ferdausi T, Miyuu T, Izawa T, Kuwamura M, Parvin R
Fatal avian pox in a backyard flock of domestic ducks in Bangladesh.
Vet Rec Case Rep e718, 2023. https://doi.org/10.1002/vrc2.718

Ono N, Fujita T, Miki M, Nishiyama K, Izawa T, Aoyama T, Kuwamura M, Fujii H, Azuma YT
Interleukin-19 gene-deficient mice promote liver fibrosis via enhanced TGF-β signaling, and the interleukin-19-CCL2 axis is important in the direction of liver fibrosis.
Biomedicines 11(7):2064, 2023. https://doi.org/10.3390/biomedicines11072064

Izawa T, Travlos GS, Cortes RA, Clayton NP, Sills RC, Pandiri AR
Absence of increased susceptibility to acetaminophen-induced liver injury in a diet induced NAFLD mouse model.
Toxicol Pathol 51(3):112-125, 2023. https://doi.org/10.1177/01926233231171101

Ando T, Izawa T, Nishida H, Akiyoshi H
Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study.
Open Vet J 13(6):742-752, 2023. http://dx.doi.org/10.5455/OVJ.2023.v13.i6.9

Hasan MM, Konishi S, Tanaka M, Izawa T, Yamate J, Kuwamura M
Disrupted neurogenesis, gliogenesis, and ependymogenesis in the Ccdc85c knockout rat for hydrocephalus model.
Cells Dev 175:203858, 2023. https://doi.org/10.1016/j.cdev.2023.203858

Takami Y, Tanaka M, Izawa T, Kuwamura M, Yamate J
The effect of lipopolysaccharide on liver homeostasis and diseases based on the mutual interaction of macrophages, autophagy, and damage-associated molecular patterns in male F344/DuCrlCrlj rats.
Vet Pathol 60(4): 461-472, 2023. https://doi.org/10.1177/03009858231173364

Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Kuwamura M, Azuma Y-T
L-arginine-induced pancreatitis aggravated by inhibiting Na⁺/Ca²⁺ exchanger 1.
J Vet Med Sci 85(6):657-666, 2023. https://doi.org/10.1292/jvms.22-0569

Nakagawa M, Izawa T, Kuwamura M, Yamate J
Analyses of damage-associated molecular patterns, particularly biglycan, in cisplatin-induced rat progressive renal fibrosis.
J Toxicol Pathol 36(3):181-185, 2023. https://doi.org/10.1293/tox.2022-0148

Yamate J, Izawa T, Kuwamura M
Macrophage pathology in hepatotoxicity.
J Toxicol Pathol 36(2):51–68, 2023. https://doi.org/10.1293/tox.2022-0112

Ito T, Tanaka T, Kiyatake I, Izawa T, Furuya M, Sasai K
Contrast-enhanced computed tomography and cross-sectional anatomy of the trunk in the brownbanded bamboo shark (Chiloscyllium punctatum).
Anat Histol Embryol 52(3):437-447, 2023. https://doi.org/10.1111/ahe.12903

安積一平, 西田英高, 田中美有, 桑村充, 嶋崎等, 田中利幸, 山本卓矢, 秋吉秀保
肩甲骨及び硬膜外脂肪に認められた特発性無菌性化膿性肉芽腫のトイプードルの1例．
日本獣医学雑誌 76(5):75-80, 2023. https://doi.org/10.12935/jvma.76.e75

Hieu HT, Tanaka M, Kuwamura M, Mashimo T, Serikawa T, Kuramoto T
The rat Downunder (Du) coat color mutation is associated with eye anomaly and embryonic lethality and maps to the 3.9-Mb region on chromosome 3.
Exp Anim 72(1):88-94, 2023. https://doi.org/10.1538/expanim.22-0086

Hatoya S, Kanegi R, Nabetani T, Oji S, Izawa T, Hirai S, Sugiura K
Atypical hypoadrenocorticism with intact zona glomerulosa of the adrenal cortex after long-term observation: A case report of a dog.
J Vet Med Sci 85(1):9-13, 2023. https://doi.org/10.1292/jvms.22-0322

 (2022)

Fujiwara S, Izawa T, Mori M, Atarashi M, Yamate J, Kuwamura M
Dietary iron overload enhances Western diet induced hepatic inflammation and alters lipid metabolism in rats sharing similarity with human DIOS.
Sci Rep 12:21414, 2022. https://doi.org/10.1038/s41598-022-25838-3

Sakamoto K, Lin B, Nunomura K, Izawa T, Nakagawa S
The K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors.
Sci Rep 12(1):8121, 2022. https://doi.org/10.1038/s41598-022-12401-3

Pervin M, Karim MR, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Possible cytoprotection of low dose lipopolysaccharide in rat thioacetamide-induced liver lesions, focusing on the analyses of hepatic macrophages and autophagy.
Toxicol Pathol 50(3):353-365, 2022. https://doi.org/10.1177/01926233221076758

Hasan MM, Konishi S, Tanaka M, Izawa T, Yamate J, Kuwamura M
Expression of CCDC85C, a causative protein for hydrocephalus, and intermediate filament proteins during lateral ventricle development in rats.
Exp Anim 71(1):100-108, 2022. https://doi.org/10.1538/expanim.21-0132

(2021)

坂口裕亮, 西田英高, 西田英高, 田中利幸, 田中美有, 金田昌啓, 淡路俊喜, 秋吉秀保, 秋吉秀保                                                                脱出した椎間板物質によって内椎骨静脈叢が背外側に変位した頸部椎間板ヘルニアの犬の1例 
日本獣医麻酔外科学雑誌(Web) 52(1) 2021年  https://doi.org/10.2327/jjvas.52.21

Wada Y, Yamazaki H, Tanaka M, Kaneguchi A, Tanaka T, Akiyoshi H, Noguchi S
Radiotherapy-induced tumor lysis syndrome in a dog with thymoma.
J Vet Med Sci 83(8):1290–1294, 2021. https://doi.org/10.1292/jvms.20-0656

Kimura K, Tsukamoto M, Yoshida T, Tanaka M, Kuwamura M, Ohtaka M, Nishimura K, Nakanishi M, Sugiura K, Hatoya S
Canine Induced Pluripotent Stem Cell Maintenance Under Feeder-Free and Chemically-Defined Conditions.
Mol Reprod Dev 88(6):395–404, 2021. https://doi.org/10.1002/mrd.23478

Azuma YT, Fujita T, Izawa T, Hirota K, Nishiyama K, Ikegami A, Aoyama T, Ike M, Ushikai Y, Kuwamura M, Fujii H, Tsuneyama K
IL-19 contributes to the development of nonalcoholic steatohepatitis by altering lipid metabolism.
Cells 10(12):3513, 2021. https://doi.org/10.3390/cells10123513

Kaneguchi A, Izawa T, Tanaka M, Suzuki H, Tani H, Kuwamura M, Yamate J
Systemic anaplastic large T-cell lymphoma with initial presentation of dysuria in a dog.
J Comp Pathol 189:26–30, 2021. https://doi.org/10.1016/j.jcpa.2021.09.006

Hoang Trung H, Yoshihara T, Nakao A, Hayashida K, Hirata Y, Shirasuna K, Kuwamura M, Nakagawa Y, Kaneko T, Mori Y, Asano M, Kuramoto T
Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.
Sci Rep 11(1):2039, 2021. https://doi.org/10.1038/s41598-021-81515-x

Matsuyama S, Pervin M, Nakagawa M, Izawa T, Kuwamura M, Yamate J
Properties of macrophages and lymphocytes appearing in rat renal fibrosis followed by repeated injection of cisplatin.
J Vet Med Sci 83(9):1435–1442, 2021. https://doi.org/10.1292/jvms.21-0341

Kobayashi Y, Watanabe N, Kitakaze T, Sugimoto K, Izawa T, Kai K, Harada, N, Yamaji R
Oleamide rescues tibialis anterior muscle atrophy of mice housed in small cages.
Br J Nutr 126(4):481–491, 2021. https://doi.org/10.1017/S0007114520004304

Koga M, Karim MR, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Appearance of heterogeneous macrophages during development of isoproterenol-induced rat myocardial fibrosis.
Toxicol Pathol 49(5):1048–1061, 2021. https://doi.org/10.1177/0192623320982526

Kuramochi M, Izawa T, Kuwamura M, Yamate J
Involvement of neutrophils in rat livers by low-dose thioacetamide administration.
J Vet Med Sci 83(3):390–396, 2021. https://doi.org/10.1292/jvms.20-0581

Numakura Y, Uemura R, Tanaka M, Izawa T, Yamate J, Kuramoto T, Kaneko T, Mashimo T, Yamamoto T, Serikawa T, Kuwamura M
PHF24 is expressed in the inhibitory interneurons in rats.
Exp Anim 70(1):137–143, 2021. https://doi.org/10.1538/expanim.20-0105

Inai Y, Izawa T, Mori M, Atarashi M, Tsuchiya S, Kuwamura M, Yamate J
Analyses of hemorrhagic diathesis in high-iron diet-fed rats.
J Toxicol Pathol 34(1):33–41, 2021. https://doi.org/10.1293/tox.2020-0004

Yamazaki H, Sasai H, Tanaka M, Tanaka T, Nishida H, Noguchi S, Kuwamura M, Akiyoshi H
Assessment of biomarkers influencing treatment success on small intestinal lymphoma in dogs.
Vet Comp Oncol 19(1):123–131, 2021. https://doi.org/10.1111/vco.12653.

Kimura K, Tsukamoto M, Tanaka M, Kuwamura M, Ohtaka M, Nishimura K, Nakanishi M, Sugiura K, Hatoya S
Efficient reprogramming of canine peripheral blood mononuclear cells into induced pluripotent stem cells.
Stem Cells Dev 30(2):79–90, 2021. https://doi.org/10.1089/scd.2020.0084

Nakagawa M, Karim MR, Izawa T, Kuwamura M, Yamate J
Immunophenotypical characterization of M1/M2 macrophages and lymphocytes in cisplatin-induced rat progressive renal fibrosis.
Cells 10(2):257, 2021. https://doi.org/10.3390/cells10020257

Rahman N, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Characterization of immature myofibroblasts of stellate cell or mesenchymal cell origin in D-galactosamine-induced liver injury in rats.
Vet Pathol 58(1):80–90, 2021. https://doi.org/10.1177/0300985820963097

(2020)

岡村 健作, 相川 諒, 田中 美有, 井澤 武史, 山手 丈至, 桑村 充
チンチラ（Chinchilla lanigera）に発生した非定型抗酸菌症.
動物臨床医学 29巻 4号 p.167–170. https://doi.org/10.11252/dobutsurinshoigaku.29.167  

Kanegae H, Tomino N, Nakamura Y, Minakawa T, Yaguchi T, Izawa T, Sano A, Ueda K
Parengyodontium album isolated from cutaneous lesions of a pacific white-sided dolphin (Lagenorhynchus obliquidens) during treatment for Paracoccidioidomycosis Ceti.
Mycopathologia 185(6):1021–1031, 2020. https://doi.org/10.1007/s11046-020-00484-3

Minakawa T, Shumoto G, Kezuka C, Izawa T, Sasaki K, Yamaguchi S, Kamezaki N, Yamate J, Konno T, Sano A, Itano EN, Wada S, Willson C, Ueda K
Seroprevalence of Antibodies Against Paracoccidioides Spp. in Captive Dolphins from Three Aquaria in Japan.
Mycopathologia 185:1013–1020, 2020. https://doi.org/10.1007/s11046-020-00501-5

Fujimoto Y, Kuwamura M, Azuma YT
Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-induced acute liver failure.
J Vet Med Sci 82(10):1450–1455, 2020. https://doi.org/10.1292/jvms.20-0344.

Tsuji Y, Kuramochi M, Golbar HM, Izawa T, Kuwamura M, Yamate J
Acetaminophen-induced rat hepatotoxicity based on m1/m2-macrophage polarization, in possible relation to damage-associated molecular patterns and autophagy.
Int J Mol Sci 21(23):8998, 2020. https://doi.org/10.3390/ijms21238998.

Harada N, Minami Y, Hanada K, Hanaoka R, Kobayashi Y, Izawa T, Sato T, Kato S, Inui H, Yamaji R
Relationship between gut environment, feces-to-food ratio, and androgen deficiency- induced metabolic disorders.
Gut Microbes 12(1):1817719, 2020. https://doi.org/10.1080/19490976.2020.1817719.

Hada N, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Effects of dexamethasone on hepatic macrophages in normal livers and thioacetamide-induced acute liver lesions in rats.
J Toxicol Pathol 33(4):237–246, 2020. https://doi.org/10.1293/tox.2020-0016.

Mori M, Izawa T, Inai Y, Aikawa R, Fujiwara S, Kuwamura M, Yamate J
Dietary iron overload differentially modulates chemically-induced liver injury in rats.
Nutrients 12(9):2784, 2020. https://doi.org/10.3390/nu12092784.

Tsukamoto M, Kimura K, Tanaka M, Kuwamura M, Ohtaka M, Nakanishi M, Sugiura K, Hatoya S
Generation of footprint-free canine induced pluripotent stem cells from peripheral blood mononuclear cells using sendai virus vector.
Mol Reprod Dev. 87(6):663–665, 2020. https://doi.org/10.1002/mrd.23349.

Hashikawa Y, Hayashi R, Tajima M, Okubo T, Azuma S, Kuwamura M, Takai N, Osada Y, Kunihiro Y, Mashimo T, Nishida K.
Generation of knockout rabbits with X-linked severe combined immunodeficiency (X-SCID) using CRISPR/Cas9.
Sci Rep 10(1):9957, 2020. https://doi.org/10.1038/s41598-020-66780-6.

Katou-Ichikawa C, Nishina H, Tanaka M, Takenaka S, Izawa T, Kuwamura M, Yamate J
Participation of somatic stem cells, labeled by a unique antibody (A3) recognizing both n-glycan and peptide, to hair follicle cycle and cutaneous wound healing in rats.
Int J Mol Sci 21(11): 3806, 2020. https://doi.org/10.3390/ijms21113806.

Takami Y, Izawa T, Tanaka M, Hatoya S, Nabetani T, Yamate J, Kuwamura M
Hepatocellular necrosis with prominent regenerative reactions in a zonisamide administrated dog.
J Vet Med Sci 82(6):704–706, 2020. https://doi.org/10.1292/jvms.20-0045.

Nishina H, Kato-Ichikawa C, Kuramochi, M, Izawa T, Kuwamura M, Yamate J
Participation of somatic stem cells, recognized by a unique A3 antibody, in mucosal epithelial regeneration in dextran sulfate sodium (DSS)-induced rat colonic lesions.
Toxicol Pathol 48(4):560–569, 2020. https://doi.org/10.1177/0192623320906817.

Morita C, Tanaka M, Noguchi S, Shimamura S, Wada Y, Izawa T, Yamate J, Kuwamura M
An aortic body carcinoma with sarcomatoid morphology and chondroid metaplasia in a French Bulldog.
J Vet Med Sci 82(5):576–579, 2020. https://doi.org/10.1292/jvms.20-0016. 

Hashimoto A, Karim MR, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Characterization of macrophages and myofibroblasts appearing in dibutyltin dichloride-induced rat pancreatic fibrosis.
Toxicol Pathol 48(3):509–523, 2020. https://doi.org/10.1177/0192623319893310.

Kuramochi M, Izawa T, Mori M, Shimamura S, Shimada T, Kuwamura M, Yamate J
Diffuse leiomyomatosis with circumferential thickening of the gastrointestinal wall, resembling human diffuse leiomyomatosis, in a young miniature dachshund.
J Vet Med Sci 82(2):139–142, 2020. https://doi.org/10.1292/jvms.19-0453.

Nishimoto Y, Nagashima S, Nakajima K, Ohira T, Sato T, Izawa T, Yamate J, Higashikawa K, Kuge Y, Ogawa M, Kojima C
Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting.
Int J Pharm 576:119021, 2020. https://doi.org/10.1016/j.ijpharm.2020.119021.

Konishi S, Tanaka N, Mashimo T, Yamamoto T, Sakuma T, Kaneko T, Tanaka M, Izawa T, Yamate J, Kuwamura M
Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus.
Exp Anim 69(1):26–33, 2020. https://doi.org/10.1538/expanim.19-0005. 

Nishitani A, Yoshihara T, Tanaka M, Kuwamura M, Asano M, Tsubota Y, Kuramoto T
Muscle weakness and impaired motor coordination in Hcn1- deficient rats.
Exp Anim 69(1):11–17, 2020. https://doi.org/10.1538/expanim.19-0067

Past publications (2000-2019)