RESEARCH

Bio measurements (Shiigi party)

Development of nanostructures for biomolecular measurement

In the field of electronics, new strategies are being developed by combining nanomaterials and nanofabrication techniques. We have developed a green electroless plating technique by self-assembly of metal nanoparticles (MNPs) with a non-toxic binder. This technology provides a uniform surface coating and thickness that reflects the diameter of the AuNPs on micrometer-sized structures, thereby saving resources and reducing environmental impact. In addition, focusing on the biocompatibility of conductive materials fabricated by this technology, we are developing applications for medical measurement.

The detection of DNA hybridization is important in the diagnosis of genetic diseases, DNA mapping, and forensic identification. We have developed a nano-gapped electrode by using a molecular electronic technology. The nano-gapped electrode leads us to detect very small electrical signal without labels. We have succeeded in observing the hybridization directly, focusing on the electrical properties of DNA.

Development of detection system using nanomaterials for microorganism

Pathogenic bacteria, cause widespread hospital-acquired infections and food poisoning, are a major public health problem worldwide. Since nanobioscience is one of the major areas of scientific progress, it should create important advances that benefit human health. We have developed a simple manipulation of gold nanoparticles that creates a structure-dependent nanometer-scale antenna on the surface of bacteria. Our studies illuminate the concept of the "effective use of light" based on the absorption and emission of light by antennas.

Development of cell activity-measurement methods

We have developed successfully an immobilization of living bacteria into the conducting polymers such as polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT). The bacteria-doped conducting polymer films is useful for bioanalysis, since it is possible for us to observe a proliferative process and various metabolism of bacterium by electrochemical and microscopic measurements. By efficiently using functions of bacteria themselves, we have considered the applications of platform to a various field such as sensing, creation of energy, and production of useful substances.

We have found a new way to circumvent these problems of standard molecularly imprinted polymer (MIP) synthetic procedures. The overoxidized polypyrrole (PPy) indicates unique and attractive features for molecular recognition. We have succeeded in sensing a variety of biomolecules (amino acids, ATP, chole acids, peptides, viruses and microorganisms) as the overoxidized PPy used for the detection platform.

Atmospheric measurements (Sadanaga party)

Development of atmospheric pollutant measurement systems

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Quantitative clarification of the photochemical oxidant production 

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Sorry... Details are under construction.

Sorry... Details are under construction.