研究実績(2016〜2020年)

Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada K, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H. Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 2020 Dec 10. doi: 10.1038/s41385-020-00358-3. Online ahead of print.

Ishida S, Kato K, Tanaka M, Odamaki T, Kubo R, Mitsuyama E, Xiao JZ, Yamaguchi R, Uematsu S, Imoto S, Miyano S. Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota. Commun Biol. 2020 Nov 18;3(1):686. doi: 10.1038/s42003-020-01416-z.

Sato S, Matsumoto N, Hisaie K, Uematsu S. Alcohol abrogates human norovirus infectivity in a pH-dependent manner. Sci Rep. 2020 Sep 28;10(1):15878. doi: 10.1038/s41598-020-72609-z.

Fujimoto K, Kimura Y, Shimohigoshi M, Satoh T, Sato S, Tremmel G, Uematsu M, Kawaguchi Y, Usui Y, Nakano Y, Hayashi T, Kashima K, Yuki Y, Yamaguchi K, Furukawa Y, Kakuta M, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy Against Pathobionts. Cell Host Microbe. 2020 Jul 3;S1931-3128(20)30344-9. doi: 10.1016/j.chom.2020.06.005.

Parbie PK, Mizutani T, Ishizaka A, Kawana-Tachikawa A, Runtuwene LR, Seki S, Abana CZ, Kushitor D, Bonney EY, Ofori SB, Uematsu S, Imoto S, Kimura Y, Kiyono H, Ishikawa K, Ampofo WK, Matano T. Fecal Microbiome Composition in Healthy Adults in Ghana. Jpn J Infect Dis. 2020 Jun 30 doi: 10.7883/yoken.JJID.2020.469.

Fujimoto K, Uematsu S. Vaccine therapy for dysbiosis-related diseases. World J Gastroenterol. 2020 Jun 7;26(21):2758-2767. doi: 10.3748/wjg.v26.i21.2758. (Review)

Takashima S, Tanaka F, Kawaguchi Y, Usui Y, Fujimoto K, Nadatani Y, Otani K, Hosomi S, Nagami Y, Kamata N, Taira K, Tanigawa T, Watanabe T, Imoto S, Uematsu S, Fujiwara Y. Proton Pump Inhibitors Enhance Intestinal Permeability via Dysbiosis of Gut Microbiota Under Stressed Conditions in Mice. Neurogastroenterol Motil. 2020 Apr 21;e13841. doi: 10.1111/nmo.13841.

Fujimoto K, Uematsu S. Development of prime-boost-type next-generation mucosal vaccines. Int Immunol. 2019 Dec 28. pii: dxz085. doi: 10.1093/intimm/dxz085. (Review)

Sugimura N, Otani K, Watanabe T, Nakatsu G, Shimada S, Fujimoto K, Nadatani Y, Hosomi S, Tanaka F, Kamata N, Taira K, Nagami Y, Tanigawa T, Uematsu S, Fujiwara Y. High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A. Sci Rep. 2019 Nov 14;9(1):16796. doi: 10.1038/s41598-019-52980-2.

Takahashi R, Amano H, Ito Y, Eshima K, Satoh T, Iwamura M, Nakamura M, Kitasato H, Uematsu S, Raouf J, Jakobsson PJ, Akira S, Majima M. Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow. Biomed Pharmacother. 2019 Nov 9;121:109581. doi: 10.1016/j.biopha.2019.109581.

Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448.

Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S. Antigen-specific Mucosal Immunity Regulates Development of Intestinal Bacteria-mediated Diseases. Gastroenterology. 2019 Aug 21. pii: S0016-5085(19)41241-9. doi: 10.1053/j.gastro.2019.08.021.

Ikeda-Matsuo Y, Miyata H, Mizoguchi T, Ohama E, Naito Y, Uematsu S, Akira S, Sasaki Y, Tanabe M. Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease. Neurobiol Dis. 2018 Nov 10. pii: S0969-9961(18)30741-1. doi: 10.1016/j.nbd.2018.11.004.

Lee EY, Zhang X, Miyamoto J, Kimura I, Taknaka T, Furusawa K, Jomori T, Fujimoto K, Uematsu S, Miki T. Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway. J Endocrinol. 2018 Dec 1;239(3):267-276. doi: 10.1530/JOE-18-0241.

Flores-Langarica A, Cook C, Müller Luda K, Persson EK, Marshall JL, Beristain-Covarrubias N, Yam-Puc JC, Dahlgren M, Persson JJ, Uematsu S, Akira S, Henderson IR, Lindbom BJ, Agace W, Cunningham AF. Intestinal CD103+CD11b+ cDC2 Conventional Dendritic Cells Are Required for Primary CD4+ T and B Cell Responses to Soluble Flagellin. Front Immunol. 2018 Oct 17;9:2409. doi: 10.3389/fimmu.2018.02409. eCollection 2018.

Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou HK, Nakajima T, Kanno T, Ouchi Y, Uematsu S, Nishimasu H, Nureki O, Tumes DJ, Shimojo N, Nakayama T. DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat Commun. 2018 Oct 12;9(1):4231. doi: 10.1038/s41467-018-06468-8.

Usui Y, Kimura Y, Satoh T, Takemura N, Ouchi Y, Ohmiya H, Kobayashi K, Suzuki H, Koyama S, Hagiwara S, Tanaka H, Imoto S, Eberl G, Asami Y, Fujimoto K, Uematsu S.Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice. Int Immunol. 2018 Jun 26;30(7):319-331. doi: 10.1093/intimm/dxy035.

Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S.Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing. Int Immunol. 2018 Apr 3;30(4):141-154. doi: 10.1093/intimm/dxy006.

Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K. Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death Differ. 2018 Mar 22. doi: 10.1038/s41418-018-0098-3. [Epub ahead of print]

Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Sci Transl Med. 2018 Feb 21;10(429). pii: eaan0333. doi: 10.1126/scitranslmed.aan0333.

Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M. Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice. J Hepatol. 2018 Feb 16. pii: S0168-8278(18)30126-0. doi: 10.1016/j.jhep.2018.02.009. [Epub ahead of print]

Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H.A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. Stem Cell Reports. 2018 Jan 9;10(1):314-328. doi: 10.1016/j.stemcr.2017.11.004. Epub 2017 Dec 7.

Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H . Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System. Front Immunol. 2017 Dec 13;8:1787. doi: 10.3389/fimmu.2017.01787. eCollection 2017. Review.

Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. J Clin Invest. 2017 Oct 2;127(10):3784-3795. doi: 10.1172/JCI92931.

Eri T, Kawahata K, Kanzaki T, Imamura M, Michishita K, Akahira L, Bannai E, Yoshikawa N, Kimura Y, Satoh T, Uematsu S, Tanaka H, Yamamoto K. Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction.Sci Rep. 2017 Apr 26;7:46037. doi: 10.1038/srep46037.

Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y.G-CSF-induced sympathetic tone provokes fever and primes anti-mobilizing functions of neutrophils via PGE2.Blood. 2017 Feb 2;129(5):587-597. doi: 10.1182/blood-2016-07-725754.

Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.Immunity. 2016 Dec 20;45(6):1299-1310. doi: 10.1016/j.immuni.2016.11.010.

Goto Y, Uematsu S, Kiyono H. Epithelial glycosylation in gut homeostasis and inflammation.Nat Immunol. 2016 Oct 19;17(11):1244-1251. doi: 10.1038/ni.3587. Review.

Takemura N, Uematsu S. Isolation and Fuctional Analysis of Lamina PropriaDendritic Cells from the Mouse Small Intestine. Methods Mol Biol. 2016;1422:181-8. doi: 10.1007/978-1-4939-3603-8_17.

Maruzuru Y, Koyanagi N, Takemura N, Uematsu S, Matsubara D, Suzuki Y, Arii J, Kato A, Kawaguchi Y. p53 is a Host Cell Regulator during Herpes Simplex Encephalitis. J Virol. 2016 May 11. pii: JVI.00846-16. [Epub ahead of print]