研究実績(2021年〜現在)

An enterococcal phage-derived enzyme suppresses graft-versus-host disease.
Fujimoto K, Hayashi T, Yamamoto M, Sato N, Shimohigoshi M, Miyaoka D, Yokota C, Watanabe M, Hisaki Y, Kamei Y, Yokoyama Y, Yabuno T, Hirose A, Nakamae M, Nakamae H, Uematsu M, Sato S, Yamaguchi K, Furukawa Y, Akeda Y, Hino M, Imoto S, Uematsu S. Nature. 2024 July. doi: 10.1038/s41586-024-07667-8.

Targeted Lysis of Staphylococcus hominis Linked to Axillary Osmidrosis Using Bacteriophage-Derived Endolysin.
Watanabe M, Uematsu M, Fujimoto K, Hara T, Yamamoto M, Miyaoka D, Yokota C, Kamei Y, Sugimoto A, Kawasaki N, Yabuno T, Sato N, Sato S, Yamaguchi K, Furukawa Y, Tsuruta D, Okada F, Imoto S, Uematsu S. J Invest Dermatol. 2024 Apr 19:S0022-202X(24)00294-X. doi: 10.1016/j.jid.2024.03.039. Online ahead of print.PMID: 38642797

Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci.
Yokota C, Fujimoto K, Yamakawa N, Kono M, Miyaoka D, Shimohigoshi M, Uematsu M, Watanabe M, Kamei Y, Sugimoto A, Kawasaki N, Yabuno T, Okamura T, Kuroda E, Hamaguchi S, Sato S, Hotomi M, Akeda Y, Ishii KJ, Yasutomi Y, Sunami K, Uematsu S. Inflamm Regen. 2023 Nov 15;43(1):55. doi: 10.1186/s41232-023-00305-2.PMID: 37964391

ggkegg: analysis and visualization of KEGG data utilizing the grammar of graphics.
Sato N, Uematsu M, Fujimoto K, Uematsu S, Imoto S. Bioinformatics. 2023 Oct 3;39(10):btad622. doi: 10.1093/bioinformatics/btad622.PMID: 37846038

The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation.
Hyodo T, Ito Y, Hosono K, Uematsu S, Akira S, Majima M, Takeda A, Amano H. In Vivo. 2022 Sep-Oct;36(5):2061-2073. doi: 10.21873/invivo.12932.PMID: 36099134

Zero-shot-capable identification of phage-host relationships with whole-genome sequence representation by contrastive learning.
Zhang YZ, Liu Y, Bai Z, Fujimoto K, Uematsu S, Imoto S. Brief Bioinform. 2023 Sep 20;24(5):bbad239. doi: 10.1093/bib/bbad239.PMID: 37466138

The microsomal prostaglandin E synthase-1/prostaglandin E2 axis induces recovery from ischaemia via recruitment of regulatory T cells.
Amano H, Eshima K, Ito Y, Nakamura M, Kitasato H, Ogawa F, Hosono K, Iwabuchi K, Uematsu S, Akira S, Narumiya S, Majima M. Cardiovasc Res. 2023 May 22;119(5):1218-1233. doi: 10.1093/cvr/cvac137.PMID: 35986688

Impact of neoadjuvant therapy on gut microbiome in patients with resectable/borderline resectable pancreatic ductal adenocarcinoma.
Takaori A, Hashimoto D, Ikeura T, Ito T, Nakamaru K, Masuda M, Nakayama S, Yamaki S, Yamamoto T, Fujimoto K, Matsuo Y, Akagawa S, Ishida M, Yamaguchi K, Imoto S, Hirota K, Uematsu S, Satoi S, Sekimoto M, Naganuma M. Pancreatology. 2023 Jun;23(4):367-376. doi: 10.1016/j.pan.2023.04.001. Epub 2023 Apr 5.PMID: 37088586

Characterization of the human gut virome in metabolic and autoimmune diseases.
Fujimoto K, Miyaoka D, Uematsu S. Inflamm Regen. 2022 Nov 1;42(1):32. doi: 10.1186/s41232-022-00218-6.PMID: 36316749

Phage therapy for Clostridioides difficile infection.
Fujimoto K, Uematsu S. Front Immunol. 2022 Oct 28;13:1057892. doi: 10.3389/fimmu.2022.1057892. eCollection 2022.PMID: 36389774

Identification of bacteriophage genome sequences with representation learning.
Bai Z, Zhang YZ, Miyano S, Yamaguchi R, Fujimoto K, Uematsu S, Imoto S. Bioinformatics. 2022 Sep 15;38(18):4264-4270. doi: 10.1093/bioinformatics/btac509.PMID: 35920769

Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer.
Masuhiro K, Tamiya M, Fujimoto K, Koyama S, Naito Y, Osa A, Hirai T, Suzuki H, Okamoto N, Shiroyama T, Nishino K, Adachi Y, Nii T, Kinugasa-Katayama Y, Kajihara A, Morita T, Imoto S, Uematsu S, Irie T, Okuzaki D, Aoshi T, Takeda Y, Kumagai T, Hirashima T, Kumanogoh A. JCI Insight. 2022 May 9;7(9):e157915. doi: 10.1172/jci.insight.157915.PMID: 35389889

Galectin-3 promotes the adipogenic differentiation of PDGFRα+ cells and ectopic fat formation in regenerating muscle.
Takada N, Takasugi M, Nonaka Y, Kamiya T, Takemura K, Satoh J, Ito S, Fujimoto K, Uematsu S, Yoshida K, Morita T, Nakamura H, Uezumi A, Ohtani N. Development. 2022 Feb 1;149(3):dev199443. doi: 10.1242/dev.199443. Epub 2022 Feb 3.PMID: 35029658

Interferon-α exerts proinflammatory properties in experimental radiation-induced esophagitis: Possible involvement of plasmacytoid dendritic cells.
Kitamura H, Tanigawa T, Kuzumoto T, Nadatani Y, Otani K, Fukunaga S, Hosomi S, Tanaka F, Kamata N, Nagami Y, Taira K, Uematsu S, Watanabe T, Fujiwara Y. Life Sci. 2022 Jan 15;289:120215. doi: 10.1016/j.lfs.2021.120215. Epub 2021 Dec 8.PMID: 34890590

Ovariectomy-Induced Dysbiosis May Have a Minor Effect on Bone in Mice.
Kosaka S, Nadatani Y, Higashimori A, Otani K, Fujimoto K, Nagata Y, Ominami M, Fukunaga S, Hosomi S, Kamata N, Tanaka F, Nagami Y, Taira K, Imoto S, Uematsu S, Watanabe T, Fujiwara Y. Microorganisms. 2021 Dec 10;9(12):2563. doi: 10.3390/microorganisms9122563.PMID: 34946163

Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial.
Yuki Y, Nojima M, Hosono O, Tanaka H, Kimura Y, Satoh T, Imoto S, Uematsu S, Kurokawa S, Kashima K, Mejima M, Nakahashi-Ouchida R, Uchida Y, Marui T, Yoshikawa N, Nagamura F, Fujihashi K, Kiyono H. Lancet Microbe. 2021 Sep;2(9):e429-e440. doi: 10.1016/S2666-5247(20)30196-8. Epub 2021 Jun 25.PMID: 35544149

Parbie PK, Mizutani T, Ishizaka A, Kawana-Tachikawa A, Runtuwene LR, Seki S, Abana CZ, Kushitor D, Bonney EY, Ofori SB, Uematsu S, Imoto S, Kimura Y, Kiyono H, Ishikawa K, Ampofo WK, Matano T. Dysbiotic Fecal Microbiome in HIV-1 Infected Individuals in Ghana. Front Cell Infect Microbiol. 2021 May 18;11:646467. doi: 10.3389/fcimb.2021.646467.

Fujimoto K, Kimura Y, Allegretti JR, Yamamoto M, Zhang YZ, Katayama K, Tremmel G, Kawaguchi Y, Shimohigoshi M, Hayashi T, Uematsu M, Yamaguchi K, Furukawa Y, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation. Gastroenterology. 2021 Feb 9;S0016-5085(21)00400-5. doi: 10.1053/j.gastro.2021.02.013.

Mukendi JPK, Nakamura R, Uematsu S, Hamano S. Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice. Parasit Vectors. 2021 Jan 22;14(1):70. doi: 10.1186/s13071-020-04561-w.