Publications

2024

原著論文

  1. Shingo Kasamatsu, Ayaka Kinno, Chiharu Miura, Jun-ichi Hishiyama, Kensuke Fukui, Shoji Kure, Kazunobu Tsumura, Tomoaki Ida, Tetsuro Matsunaga, *Takaaki Akaike, *Hideshi Ihara Quantitative profiling of supersulfides naturally occurring in dietary meats and beans. Analytical Biochemistry 685, 115392 (2024)
  2. Kemper Young, Setsuko Yamane, Elmira Abbasi GharehTapeh, Shingo Kasamatsu, Hideshi Ihara, Urara Hasegawa Manganese Porphyrin-Containing Polymeric Micelles: A Novel Approach for Intracellular Catalytic Formation of Per/Polysulfide Species from a Hydrogen Sulfide Donor. Advanced healthcare materials 13, 2302429 (2024)

2023

原著論文

  1. Shingo Kasamatsu, Takuma Owaki, Somei Komae, Ayaka Kinno, Tomoaki Ida, Takaaki Akaike, Hideshi Ihara Untargeted polysulfide omics analysis of alternations in polysulfide production during the germination of broccoli sprouts. Redox Biology 67, 102785 (2023)
  2. Shingo Kasamatsu, Akira Nishimura, Md. Morshedul Alam, Masanobu Morita, Kakeru Shimoda, Tetsuro Matsunaga, Minkyung Jung, Seiryo Ogata, Uladzimir Barayeu, Tomoaki Ida, Motohiro Nishida, Akiyuki Nishimura, Hozumi Motohashi, Takaaki Akaike Supersulfide catalysis for nitric oxide and aldehyde metabolism. Science Advances 9, eadg8631 (2023)
  3. Shoma Araki, Tsuyoshi Takata, Katsuhiko Ono, Tomohiro Sawa, Shingo Kasamatsu, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Yasuo Watanabe, Yukihiro Tsuchiya Cystathionine γ-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism International Journal of Molecullar Sciences 24(12), 9982(2023)
  4. Kana Matsukura, Somei Komae, Shingo Kasamatsu, Hideshi Ihara 2-Oxo-imidazole dipeptides inhibit peroxynitrite-dependent tyrosine nitration Biochemical and biophysical research communications 668, 77-81(2023）
  5. Ayaka Kinno, Shingo Kasamatsu, Takaaki Akaike, Hideshi Ihara Reactive Sulfur Species Omics Analysis in the Brain Tissue of the 5xFAD Mouse Model of Alzheimer’s Disease, Antioxidants 12, 1105(2023)

2022

原著論文

  1. Shingo Kasamatsu, Ayaka Kinno, Jun-ichi Hishiyama, Takaaki Akaike, Hideshi Ihara Development of methods for quantitative determination of the total and reactive polysulfides: Reactive polysulfide profiling in vegetables, Food Chemistry, 413, 135610, (2022)
  2. Christopher H. Switzer, Shingo Kasamatsu, Hideshi Ihara, and Philip Eaton SOD1 is an essential H2S detoxifying enzyme, Proc Natl Acad Sci U S A, Jan 17;120(3):e2205044120. doi:10.1073/ pnas.2205044120. Epub 2023 Jan 11 ,(2022)
  3. Somei Komae, Shingo Kasamatsu, Koji Uchida, Hideshi Ihara, Quantitative Determination of 2-Oxo-Imidazole-Containing Dipeptides by High-Performance Liquid Chromatography/Tandem Mass Spectrometry Antioxidants, 11(12), 2401,(2022)
  4. Rajalakshmi Balasubramanian, Koichi Hori, Takayuki Shimizu, Shingo Kasamatsu, Kae Okamura, Kan Tanaka, Hideshi Ihara, Shinji Masuda,The Sulfide-Responsive SqrR/BigR Homologous Regulator YgaV of Escherichia coli Controls Expression of Anaerobic Respiratory Genes and Antibiotic Tolerance, Antioxidants, 11(12), 2359,(2022)
  5. Somei Komae, Shingo Kasamatsu, Hideshi Ihara, 2-Oxo-imidazole dipeptides in meat, Bioscience, Biotechnology, and Biochemistry, zbac138,(2022)

 

総説

  1. 食品の超硫黄による環境化学物質の毒性制御, 笠松真吾、居原秀, Medical Science Digest, Vol. 49, No1 (2023), 25-28, (2022)

 

2021

原著論文 

  1. Ueda Y, Zhao W, Ihara H, Imahori Y, Tsantili E, Wendakoon SK, Chambers A, Bai J. Functional Characteristics of Aldehyde Dehydrogenase and Its Involvement in Aromatic Volatile Biosynthesis in Postharvest Banana Ripening.  Foods 11: 347, (2022)
  2. Kasamatsu S, Tsutsuki H, Ida T, Sawa T, Watanabe Y, Akaike T, Ihara H. Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants. Nitric Oxide 120: 44-52, (2022)
  3. Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma Y, Ihara H, Kumagai Y, Akaike T, Eaton P, Uchida K, Nishida M. Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression. Sci Signal 15: eabj0644, (2022)
  4. Kasamatsu S, Komae S, Matsukura K, Kakihana Y, Uchida K, Ihara H. 2-Oxo-Imidazole-Containing Dipeptides Play a Key Role in the Antioxidant Capacity of Imidazole-Containing Dipeptides. Antioxidants 10: 1434, (2021)
  5. Marutani E, Morita M, Hirai S, Kai S, Grange MH R, Miyazaki Y, Nagashima F, Traeger L, Magliocca A, Ida T, Matsunaga T, Flicker R D, Corman B, Mori N, Yamazaki Y, Batten A, Li R, Tanaka T, Ikeda T, Nakagawa A, Atochin N D, Ihara H, Olenchock A B, Shen X, Nishida M, Hanaoka K, Kevil G C, Xian M, Bloch B D, Akaike T, Hindle G A, Motohashi H, Ichinose F. Sulfide catabolism ameliorates hypoxic brain injury. Nature Commun 12: 3108, (2021)

 

総説

  1. Sawa T, Takata T, Matsunaga T, Ihara H, Motohashi H, Akaike T. Chemical Biology of Reactive Sulfur Species: Hydrolysis-Driven Equilibrium of Polysulfides as a Determinant of Physiological Functions. Antioxid Redox Signal 36: 4-6, (2021)
  2. 笠松真吾, 居原 秀.  計測技術：質量分析法を用いた生体内硫黄分子の解析　実験医学2021年8月号「どうして自分だけ狙われる？選択的オートファジー」 Vol.39 No.13 p2106-2108, (2021)
  3. 笠松真吾, 居原 秀.  超硫黄分子の新規分析方法の開発  生化学  93: 613-620, (2021)

 

2020

原著論文

  1. Kakihana Y, Kasamatsu S, Uchida K, Ihara H. Distribution and quantitative analysis of homoanserine and its 2-oxo derivative in mouse tissues.  Free Radic Res 55: 579-588, (2021)
  2. Cheah P-S, Prabhakar S, Yellen D, Beauchamp RL, Zhang X, Kasamatsu S, Bronson RT, Thiele EA, Kwiatkowski DJ, Stemmer-Rachamimov A, György B, Ling K-H, Kaneki M, Tannous BA, Ramesh V, Maguire CA, Breakefield XO. Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin.  Science Advances 7: eabb1703, (2021)
  3. Kobayashi M, Kasamatsu S, Shinozaki S, Yasuhara S, Kaneki M. Myostatin deficiency not only prevents muscle wasting but also improves survival in septic mice.  American Journal of Physiology-Endocrinology and Metabolism 320: E1510-E159, (2021)
  4. Kasamatsu S, Kakihana Y, Koga T, Yoshioka H, Ihara H. Generation of Rat Monoclonal Antibody to Detect Hydrogen Sulfide and Polysulfides in Biological Samples.  Antioxidants 9: 1160,(2020)
  5. Kasamatsu S, Ida T, Koga T, Asada K, Motohashi H, Ihara H, Akaike T. High Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species. Antioxid Redox Signal 34: 1407-1419, (2021)
  6. Tsutsuki H, Kasamatsu S, Kunieda K, Ida T, Sawa T, Sasakawa N, Akaike T, Ihara H. 8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells. Biochem Biophys Res Commun 526(1): 225-230, (2020)

 

総説

  1. Kasamatsu S, Ihara H. Regulation of redox signaling by reactive sulfur species. J Clin Biochem Nutr 68: 111-115, (2021)
  2. Sawa T, Motohashi H, Ihara H, Akaike T. Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides.  Biomolecules 10: 1245, (2020)
  3. Kasamatsu S. Persulfide-Dependent Regulation of Electrophilic Redox Signaling in Neural Cells.  Antioxid Redox Signal 33: 1320-1331, (2020）
  4. 垣花優希, 笠松真吾, 居原 秀. 酸化イミダゾールジペプチドによる生体機能調節　実験医学増刊 「食と健康を結ぶメディカルサイエンス」Vol.38 No.10 p67-73, (2020)

 

2019

原著論文

  1. Zhang T, Ono K, Tsutsuki H, Ihara H, Islam W, Akaike T, Sawa T. Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock. Cell Chem Biol. 26(5):686-698.e4. (2019)

 

  1. Kishimoto Y, Kasamatsu S, Yanai S, Endo S, Akaike T, Ihara H. 8-Nitro-cGMP attenuates context-dependent fear memory in mice. Biochem Biophys Res Commun. 511(1):141-147.(2019)

 

  1. Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T. Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis. Redox Biol. 21:101096. (2019)

 

  1. Kakinohana M, Marutani E, Tokuda K, Kida K, Kosugi S, Kasamatsu S, Magliocca A, Ikeda K, Kai S, Sakaguchi M, Hirai S, Xian M, Kaneki M, Ichinose F. Breathing hydrogen sulfide prevents delayed paraplegia in mice. Free Radic Biol Med. 1;131:243-250. (2019)

 

  1. Ihara H, Kakihana Y, Yamakage A, Kai K, Shibata T, Nishida M, Yamada KI, Uchida K. 2-Oxo-histidine-containing dipeptides are functional oxidation products. J Biol Chem. 294(4):1279-1289. (2019)

 

  1. Takata T, Kimura J, Ihara H, Hatano N, Tsuchiya Y, Watanabe Y. Redox regulation of Ca(2+)/calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residue. Free Radic Biol Med. 130:99-106. (2019)

 

  1. Kishimoto Y, Akaike T, Ihara H. SNAP-25 S-Guanylation and SNARE Complex Formation. Methods Mol Biol. 1860:163-173. (2019)

 

総説

  1. 居原秀, 本橋ほづみ, 赤池孝章.　活性硫黄研究の新展開. 生化学. 91, 388-398 (2019)

 

 

2018

原著論文

  1. Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H. Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons. Biochem Biophys Res Commun. 495(3):2165-2170. (2018)

 

総説

  1. 渡邊泰男, 居原秀. 活性イオウとNOシグナル. 実験医学増刊. 147, 656-661 (2018)

 

  1. 津々木博康, 澤智裕, 居原秀.タンパク質・核酸の分子修飾　ニトロ化・S-グアニル化. 生体の科学. 69, 450-451 (2018)

 

 

2017

原著論文

  1. Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H. 8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25. ACS Chem Neurosci. 9(2):217-223. (2017)

 

  1. Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nat Commun. 8(1):1177. (2017)

 

  1. Ihara H, Kasamatsu S, Kitamura A, Nishimura A, Tsutsuki H, Ida T, Ishizaki K, Toyama T, Yoshida E, Abdul Hamid H, Jung M, Matsunaga T, Fujii S, Sawa T, Nishida M, Kumagai Y, Akaike T. Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells. Chem Res Toxicol. 30(9):1673-1684. (2017)

 

  1. Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y. Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue. Biochem J. 474(15):2547-2562. (2017)

 

  1. Kikugawa M, Ida T, Ihara H, Sakamoto T. Ferulic acid and its water-soluble derivatives inhibit nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes. Biosci Biotechnol Biochem. 81(8):1607-1611. (2017)

 

  1. Hoshino M, Kaneko K, Miyamoto Y, Yoshimura K, Suzuki D, Akaike T, Sawa T, Ida T, Fujii S, Ihara H, Tanaka J, Tsukuura R, Chikazu D, Mishima K, Baba K, Kamijo R. 8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage. Free Radic Biol Med. 110:63-71. (2017)

 

  1. Ikeda M, Ishima Y, Shibata A, Chuang VTG, Sawa T, Ihara H, Watanabe H, Xian M, Ouchi Y, Shimizu T, Ando H, Ukawa M, Ishida T, Akaike T, Otagiri M, Maruyama T. Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach. Anal Chim Acta. 969:18-25. (2017).

 

  1. Ono K, Jung M, Zhang T, Tsutsuki H, Sezaki H, Ihara H, Wei FY, Tomizawa K, Akaike T, Sawa T. Synthesis of l-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome. Free Radic Biol Med. 106:69-79. (2017)

 

  1. Ihara H, Kitamura A, Kasamatsu S, Ida T, Kakihana Y, Tsutsuki H, Sawa T, Watanabe Y, Akaike T. Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation. Biochem J. 74(7):1149-1162. (2017)

 

総説

  1. Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T. Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells. Free Radic Biol Med. 109:132-140. (2017)

 

  1. 笠松真吾、守田匡伸、赤池孝章　レドックスシグナルの活性イオウ分子制御　ファルマシア 53, 210–214 (2017)

 

 

2016

原著論文

  1. Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Abdul Hamid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T. Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1. Biochem Biophys Res Commun. 480(2):180-186. (2016)

 

  1. Sternberg JR, Severi KE, Fidelin K, Gomez J, Ihara H, Alcheikh Y, Hubbard JM, Kawakami K, Suster M, Wyart C. Optimization of a Neurotoxin to Investigate the Contribution of Excitatory Interneurons to Speed Modulation In Vivo. Curr Biol. 26(17):2319-28. (2016)

 

  1. Tsutsuki H, Jung M, Zhang T, Ono K, Ida T, Kunieda K, Ihara H, Akaike T, Sawa T. Endogenous occurrence of protein S-guanylation in Escherichia coli: Target identification and genetic regulation. Biochem Biophys Res Commun. 478(1):7-11. (2016)

 

  1. Hattori H, Tsutsuki H, Nakazawa M, Ueda M, Ihara H, Sakamoto T. Naringin lauroyl ester inhibits lipopolysaccharide-induced activation of nuclear factor κB signaling in macrophages. Biosci Biotechnol Biochem. 80(7):1403-9.(2016)

 

  1. Kikugawa M, Tsutsuki H, Ida T, Nakajima H, Ihara H, Sakamoto T. Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation. Biosci Biotechnol Biochem. 80(3):547-53. (2016)

 

総説

  1. Kasamatsu S, Nishimura A, Morita M, Matsunaga T, Abdul Hamid H, Akaike T. Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation. Molecules. 21(12). pii: E1721. (2016)

 

  1. 笠松真吾、藤井重元、赤池孝章　酸化ストレスシグナルと8-ニトロ-cGMPによる感染防御機構　医学のあゆみ「マクロファージのすべて」259, 397–401 (2016)

 

  1. 笠松真吾、藤井重元、赤池孝章　活性イオウ分子種によるタンパク質チオール修飾：ポリスルフィド化タンパク質解析の最先端技法　薬理学会誌　147, 299–302（2016）

 

  1. 居原秀. 活性イオウ分子による細胞毒性の調節機構. 日本薬理学雑誌. 147, 290-293 (2016)

 

  1. Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T. Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides. Arch Biochem Biophys. 595:140-6. (2016)

 

  1. Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T. Redox signaling regulated by electrophiles and reactive sulfur species. J Clin Biochem Nutr. 58(2):91-8. (2016)

 

 

2015

原著論文

  1. Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y. Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides. Chem Res Toxicol. 28(9):1796-802. (2015)

 

  1. Kunieda K, Tsutsuki H, Ida T, Kishimoto Y, Kasamatsu S, Sawa T, Goshima N, Itakura M, Takahashi M, Akaike T, Ihara H. 8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP25. ACS Chem Neurosci. 6(10):1715-25. (2015)

 

  1. Honda K, Yamada N, Yoshida R, Ihara H, Sawa T, Akaike T, Iwai S. 8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis. Plant Cell Physiol. 56(8):1481-9. (2015)

 

  1. Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma YT, Inui T, Kamiya A, Sawa A, Takeuchi T. Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. J Biol Chem. 290(23):14493-503. (2015)

 

総説

  1. 笠松真吾、井田智章、藤井重元、赤池孝章　活性イオウ分子による酸化・ニトロ化ストレス制御　Respiratory Medical Research 3, 70-75 (2015)

 

  1. 居原秀, 大内雅也. RSSの生体内検出とイメージング. 細胞工学. 34, 397-401 (2015)

 

 

2014

原著論文

  1. Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. Proc Natl Acad Sci USA. 111(21):7606-11. (2014)

 

  1. Kasamatsu S, Watanabe Y, Sawa T, Akaike T, Ihara H. Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons. Biochem J. 459(2):251-63. (2014)

 

  1. Ogawa M, Takano K, Kawabe K, Moriyama M, Ihara H, Nakamura Y. Theophylline potentiates lipopolysaccharide-induced NO production in cultured astrocytes. Neurochem Res. 39(1):107-16. (2014)

 

 

2013

原著論文

  1. Kajiwara A, Tsuchiya Y, Takata T, Nyunoya M, Nozaki N, Ihara H, Watanabe Y. Nitric oxide enhances increase in cytosolic Ca2+ and promotes nicotine-triggered MAPK pathway in PC12 cells. Nitric Oxide. 34:3-9. (2013)

 

  1. Mori H, Tone Y, Shimizu K, Zikihara K, Tokutomi S, Ida T, Ihara H, Hara M. Studies on fish scale collagen of Pacific saury (Cololabis saira). Mater Sci Eng C Mater Biol Appl. 33(1):174-81. (2013)

 

  1. Sakamoto T, Inui M, Yasui K, Hosokawa S, Ihara H. Substrate specificity and gene expression of two Penicillium chrysogenum α-L-arabinofuranosidases (AFQ1 and AFS1) belonging to glycoside hydrolase families 51 and 54. Appl Microbiol Biotechnol. 97(3):1121-30. (2013)

 

総説

  1. 居原秀, 井田智章, 赤池孝章.活性酸素シグナルの調節機構-ROS毒性説から脱却した新たな概念. フレグランスジャーナル. 41, 75-80 (2013)

 

  1. 居原秀.レドックスメタボロミクス. 医学のあゆみ. 247, 832-838 (2013)

 

  1. Sawa T, Ihara H, Ida T, Fujii S, Nishida M, Akaike T. Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide. Nitric Oxide. 34:10-8. (2013)

 

 

2012

原著論文

  1. Ihara H, Yamamoto H, Ida T, Tsutsuki H, Sakamoto T, Fujita T, Okada T, Kozaki S. Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes. Biosci Biotechnol Biochem. 76(10):1843-8. (2012)
  2. Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M. Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation. Infect Immun. 80(11):3939-51.(2012)

 

  1. Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T. Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Nat Chem Biol. 8(8):714-24. (2012)

 

  1. Maeda R, Ida T, Ihara H, Sakamoto T. Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera. Biosci Biotechnol Biochem. 76(5):1032-4.(2012)

 

  1. Maeda R, Ida T, Ihara H, Sakamoto T. Immunostimulatory activity of polysaccharides isolated from Caulerpa lentillifera on macrophage cells. Biosci Biotechnol Biochem. 76(3):501-5.(2012)

 

  1. Yamamoto H, Ida T, Tsutsuki H, Mori M, Matsumoto T, Kohda T, Mukamoto M, Goshima N, Kozaki S, Ihara H. Specificity of botulinum protease for human VAMP family proteins. Microbiol Immunol. 56(4):245-53. (2012)

 

  1. Ahmed KA, Sawa T, Ihara H, Kasamatsu S, Yoshitake J, Rahaman MM, Okamoto T, Fujii S, Akaike T. Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signaling. Biochem J. 441(2):719-30. (2012)

 

 

2011

原著論文

  1. Miyamoto Y, Sakai R, Maeda C, Takata T, Ihara H, Tsuchiya Y, Watanabe Y. Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells. Nitric Oxide 25(3):344-9. (2011)

 

  1. Ihara H, Ahtesham AK, Ida T, Kasamatsu S, Kunieda K, Okamoto T, Sawa T, Akaike T. Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3′,5′-cyclic monophosphate formed in glia cells. Nitric Oxide 25(2):169-75. (2011)

 

  1. Sakamoto T, Ogura A, Inui M, Tokuda S, Hosokawa S, Ihara H, Kasai N. Identification of a GH62 α-L-arabinofuranosidase specific for arabinoxylan produced by Penicillium chrysogenum. Appl Microbiol Biotechnol.90(1):137-46. (2011)

 

  1. Yasuda K, Itakura M, Aoyagi K, Sugaya T, Nagata E, Ihara H, Takahashi M. PKC-dependent inhibition of CA2+-dependent exocytosis from astrocytes. Glia. 59(1):143-51. (2011)

 

総説

  1. 居原秀, 井田智章.硫化水素と硫化水素シグナル関連物質の検出・定量. 実験医学増刊. 30, 2884-2889 (2012)

 

  1. 岡本竜哉, 居原秀, 赤池孝章.喫煙と酸化ストレスOxidative stress induced by cigarette smoking　最新精神医学. 16, 431-439 (2011)

 

  1. Sawa T, Ihara H, Akaike T. Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile. Curr Top Med Chem. 11(14):1854-60. (2011)

 

  1. Ihara H, Sawa T, Nakabeppu Y, Akaike T. Nucleotides function as endogenous chemical sensors for oxidative stress signaling. J Clin Biochem Nutr. 48(1):33-9. (2011)

 

 

2010以前

原著論文

  1. Mino M, Ihara H, Kozaki S, Kondo T, Takeshita A, Kusakabe KT, Okada T. Effects of low protein intake on the development of the remaining kidney in subtotally nephrectomized immature rats: expression of inducible and endothelial NO synthase. Med Mol Morphol. 43(2):116-22 (2010)

 

  1. Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M, Akaike T. The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response. J Biol Chem. 285(31):23970-84.(2010)

 

  1. Sakamoto T, Tsujitani Y, Fukamachi K, Taniguchi Y, Ihara H. Identification of two GH27 bifunctional proteins with beta-L-arabinopyranosidase/alpha-D-galactopyranosidase activities from Fusarium oxysporum. Appl Microbiol Biotechnol. 86(4):1115-24. (2010)

 

  1. Nakajima H, Amano W, Kubo T, Fukuhara A, Ihara H, Azuma YT, Tajima H, Inui T, Sawa A, Takeuchi T. Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death. J Biol Chem. 284(49):34331-41. (2009)

 

  1. Sakai F, Ihara H, Aoyama K, Igarashi H, Yanahira S, Ohkubo T, Asao T, Kozaki S. Characteristics of enterotoxin H-producing Staphylococcus aureus isolated from clinical cases and properties of the enterotoxin productivity. J Food Prot. 71(9):1855-60. (2008)

 

  1. Ihara H, Himeno M. Study of the irreversible binding of Bacillus thuringiensis Cry1Aa to brush border membrane vesicles from Bombyx mori midgut. J Invertebr Pathol. 98(2):177-83. (2008)

 

  1. Song T, Hatano N, Kambe T, Miyamoto Y, Ihara H, Yamamoto H, Sugimoto K, Kume K, Yamaguchi F, Tokuda M, Watanabe Y. Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II. Biochem J 412(2):223-31. (2008)

 

  1. Ida T, Hara M, Nakamura Y, Kozaki S, Tsunoda S, Ihara H. Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide. Neurosci Lett 432(3):232-6. (2008)

 

  1. Tsukamoto K, Kozai Y, Ihara H, Kohda T, Mukamoto M, Tsuji T, Kozaki S. Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D. Microb Pathog 44(6):484-93. (2008)

 

  1. Izawa T, Takenaka S, Ihara H, Kotani T, Yamate J, Franklin RJ, Kuwamura M. Cellular responses in the spinal cord during development of hypomyelination in the mv rat. Brain Res 1195:120-9. (2008)

 

  1. Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T. Protein S-guanylation by the biological signal 8-nitroguanosine 3′,5′-cyclic monophosphate. Nat Chem Biol;3(11):727-35. (2007)

 

  1. Ihara H, Tsutsuki H, Ida T, Kozaki S, Tsuyama S, Moss J. Alternative polyadenylation sites of human endothelial nitric oxide synthase mRNA. Biochem Biophys Res Commun;363(1):146-52. (2007)

 

  1. Sakamoto T, Taniguchi Y, Suzuki S, Ihara H, Kawasaki H. Characterization of Fusarium oxysporum beta-1,6-galactanase, an enzyme that hydrolyzes larch wood arabinogalactan. Appl Environ Microbio;73(9):3109-12. (2007)

 

  1. Kohda T, Ihara H, Seto Y, Tsutsuki H, Mukamoto M, Kozaki S. Differential contribution of the residues in C-terminal half of the heavy chain of botulinum neurotoxin type B to its binding to the ganglioside GT1b and the synaptotagmin 2/GT1b complex. Microb Pathog. 42(2-3):72-9. (2007)

 

  1. Tsutsuki H, Kohda T, Hara M, Kozaki S, Ihara H. Nitric oxide inhibits depolarization-evoked glutamate release from rat cerebellar granule cells. Nitric Oxide. 16(2):217-27.

 

  1. Song T, Sugimoto K, Ihara H, Mizutani A, Hatano N, Kume K, Kambe T, Yamaguchi F, Tokuda M, Watanabe Y. p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase. Biochem J. 401(2):391-8.

 

  1. Ihara H, Kuwamura M, Atsuta M, Nihonmatsu I, Okada T, Mukamoto M, Kozaki S. Expression of neuronal nitric oxide synthase variant, nNOS-mu, in rat brain. Nitric Oxide. 15(1):13-9. (2006)

 

  1. Nakamura Y, Kitagawa T, Ihara H, Kozaki S, Moriyama M, Kannan Y. Potentiation by high potassium of lipopolysaccharide-induced nitric oxide production from cultured astrocytes. Neurochem Int. 48(1):43-9. (2006)

 

  1. Tsukamoto K, Kohda T, Mukamoto M, Takeuchi K, Ihara H, Saito M, Kozaki S. Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins. J Biol Chem. 280(42):35164-71. (2005)

 

  1. Kobayashi R, Kohda T, Kataoka K, Ihara H, Kozaki S, Pascual DW, Staats HF, Kiyono H, McGhee JR, Fujihashi K. A novel neurotoxoid vaccine prevents mucosal botulism. J Immunol. 174(4):2190-5. (2005)

 

  1. Nishimura K, Hamashita K, Okamoto Y, Kawahara F, Ihara H, Kozaki S, Ohnishi Y, Yamasaki S. Differential effects of interferon-gamma on production of trypanosome-derived lymphocyte-triggering factor by Trypanosoma brucei gambiense and Trypanosoma brucei brucei. J Parasitol. 90(4):740-5. (2004)

 

  1. Sakamoto T, Ihara H, Shibano A, Kasai N, Inui H, Kawasaki H. Molecular characterization of a Penicillium chrysogenum exo-1,5-alpha-L-arabinanase that is structurally distinct from other arabinan-degrading enzymes. FEBS Lett. 560(1-3):199-204. (2004)

 

  1. Ihara H, Kohda T, Morimoto F, Tsukamoto K, Karasawa T, Nakamura S, Mukamoto M, Kozaki S. Sequence of the gene for Clostridium botulinum type B neurotoxin associated with infant botulism, expression of the C-terminal half of heavy chain and its binding activity. Biochim Biophys Acta. 1625(1):19-26. (2003)

 

  1. Tsukamoto K, Mukamoto M, Kohda T, Ihara H, Wang X, Maegawa T, Nakamura S, Karasawa T, Kozaki S. Characterization of Clostridium butyricum neurotoxin associated with food-borne botulism. Microb Pathog. 33(4):177-84. (2002)

 

  1. Tsuyama S, Yamazaki E, Tomita T, Ihara H, Takenaka S, Kato K and Kozaki S. Characterization of a novel monoclonal antibody that senses nitric oxide-dependent activation of soluble guanylate cyclase. FEBS Lett. 455, 291-294. (1999)

 

  1. Novoradovsky A, Brantly ML, Waclawiw MA, Chaudhary PP, Ihara H, Qi L, Eissa NT, Barnes PM, Gabriele KM, Ehrmantraut ME, Rogliani P and Moss J. Endothelial nitric oxide synthase as a potential susceptibility gene in the pathogenesis of emphysema in α1-antitrypsin deficiency. Am. J. Respir. Cell Mol. Biol. 20, 441-447. (1999)

 

  1. Ihara H, Uemura T, Masuhara M, Ikawa S, Sugimoto K, Wadano A and Himeno M. Purification and partial amino acid sequences of the binding protein from Bombyx mori for CryIAa δ-endotoxin of Bacillus thuringiensis. Comp. Biochem. Physiol. 120, 197-204. (1998)

 

  1. Ishigami M, Ihara H and H S. Molecular evolution of aspartyl tRNA synthetases and origin of universal genetic code and urkingdoms of living things. Viva Origino. 25, 73-86. (1997)

 

  1. Ishigami M, Ihara H and H S. Molecular evolution of aminoacyl tRNA synthetases and origin of universal genetic code. Proceedings of the 5th International Conference on Bioastronomy 483-489. (1997)

 

  1. Inui H, Yamaguchi Y, Ishigami O, Kawaguchi S, Yamada T, Ihara H. and Hirano S. Three extracellular chitinases in suspension-cultured rice cells elicited by N-acetylchitooligosaccharides. Biosci. Biotechnol. Biochem. 60, 1956-1961. (1996)

 

  1. Himeno M. and Ihara H. Mode of action of δ-endotoxin from Bacillus thuringiensis var. aizawai. In Molecular action of insecticides on ion channels ACS symposium series (JM, C., ed.). American Chemical Society, Washington DC pp. 330-343. (1995)

 

  1. Ihara H, Kuroda E, Wadano A and Himeno M. Specific toxicity of δ-endotoxins from bacillus thuringiensis to bombyx mori. Biosci. Biotechnol. Biochem. 57, 200-204. (1993)

 

  1. UemuraT, Ihara H, Wadano A and Himeno M. Fluorometric Assay of Potential Change of Bombyx mori Midgut Brush Border Membrane Induced by δ-Endotoxin from Bacillus thuringiensis. Biosci. Biotechnol. Biochem. 56, 1976-1979. (1992)

 

  1. Wadano A, Miura K, Ihara H, Kondo N and Taniguchi M. Purification and some properties of isocitrate dehydrogenase of a blowfly Aldrichina grahami. Comp. Biochem. Physiol. 94, 189-194. (1989)

 

総説

  1. Akaike T, Fujii S, Sawa T, Ihara H. Cell signaling mediated by nitrated cyclic guanine nucleotide. Nitric Oxide. 23(3):166-74. (2010)

 

  1. 小崎俊司, 居原秀.クロストリジウム神経毒素の受容体認識. 実験医学増刊. 27, 158-165 (2009)

 

  1. 居原秀, 小崎俊司.細菌性神経毒素とガングリオシド. 生体の科学. 60, 228-233 (2009)