Publication

(2005-present)

 

　2024　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Nishiyama K, Horikoshi J, Maehara T, Tanaka M, Tanida T, Kawada K, Takeshita S, Ono N, Izawa T,  Kuwamura M, Azuma YT. Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid. J Pharmacol Sci. in press.
  2. Nishiyama K, Kato Y, Nishimura A, Mi X, Nagata R, Mori Y, Azuma YT, Nishida M. Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression. Int J Mol Sci. 25(4):2401. doi: 10.3390/ijms25042401.
  3. Nishiyama K. The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases. J Pharmacol Sci. 154(2):108-112. 
  4. Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Fujita T, Kuwamura M, Azuma YT. Functional role of IL-19 in a mouse model of L-arginine-induced pancreatitis and related lung injury. Experimental Animals. in press.
　2023　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. 西山和宏. 生体内での銅の役割に対する最近の知見. 日本薬理学雑誌. 158(5):420.
  2. Ono N, Fujita T, Miki M, Nishiyama K, Izawa T, Aoyama T, Kuwamura M, Fujii H, Azuma YT. Interleukin-19 gene-deficient mice promote liver fibrosis via enhanced TGF-b signaling, and the interleukin-19-CCL2 axis is important in the direction of liver fibrosis. Biomedicines. 11(7):2064.
  3. 西山和宏. 腸内環境とレドックス. 日本薬理学雑誌. 158(4):338.
  4. Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Kuwamura M, Azuma YT. L-arginine-induced pancreatitis aggravated by inhibiting Na+/Ca2+ exchanger 1. J. Vet. Med. Sci. 85(6):657-666.
  5. Numaga-Tomita T, Shimauchi T, Kato Y, Nishiyama K, Nishimura A, Sakata K, Inada H, Kita S, Iwamoto T, Nabekura J, Birnbaumer L, Mori Y, Nishida M. Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery. Br. J. Pharmacol. 180(1):94-110.
  6. Nishiyama K, Ariyoshi K, Nishimura A, Kato Y, Mi X, Kurose H, Kim SG, Nishida M. Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis. Int. J. Mol. Sci. 24(4):3800.
  7. Tang X, Nishimura A, Ariyoshi K, Nishiyama K, Kato Y, Vasileva EA, Mishchenko NP, Fedoreyev SA, Stonik VA, Kim HK, Han J, Kanda Y, Umezawa K, Urano Y, Akaike T, Nishida M. Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice. Mar. Drugs. 21(1):52.
  8. 東　泰孝．薬理学関連科目の成績評価に関する年次推移．大阪公立大学大学教育 1: 3-9.
　2022　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. 小野尚重，東　泰孝．臓器間ネットワークと腸内細菌に関する最近の話題．日本薬理学雑誌 157(5):321-324.
  2. Kato Y, Nishiyama K, Man Lee J, Ibuki Y, Imai Y, Noda T, Kamiya N, Kusakabe T, Kanda Y, Nishida M. TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation. Int. J. Mol. Sci. 24(1):102.
  3. Oda S#, Nishiyama K#, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, Kato Y, Numaga-Tomita T, Kaneko T, Mangmool S, Kuroda T, Okubo R, Sanbo M, Hirabayashi M, Sato Y, Nakagawa Y, Kuwahara K, Nagata R, Iribe G, Mori Y, Nishida M. Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors. Nature Commun. 13(1):6374. #Contributed equally.
  4. Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y. Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress. Redox Biol. 57:102514.
  5. Shimauchi T, Numaga-Tomita T, Kato Y, Morimoto H, Sakata K, Matsukane R, Nishimura A, Nishiyama K, Shibuta A, Horiuchi Y, Kurose H, Kim SG, Urano Y, Ohshima T, Nishida M. A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia. Cells. 11(13):2041.
  6. Ono N, Suzuki S, Kawada K, Yamaguchi T, Azuma YT. Stress decreases contraction of the colon, and the effects of stress are different among the regions of the colon. J. Vet. Med. Sci. 84(8):1061-1064.
  7. Nishiyama K, Nishimura A, Shimoda K, Tanaka T, Kato Y, Shibata T, Tanaka H, Kurose H, Azuma YT, Ihara H, Kumagai Y, Akaike T, Eaton P, Uchida K, Nishida M. Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression. Sci. Signal. 15(716):eabj0644. 
　2021　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Azuma YT, Fujita T, Izawa T, Hirota K, Nishiyama K, Ikegami A, Aoyama T, Ike M, Ushikai Y, Kuwamura M, Fujii H, Tsuneyama K. IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism. Cells. 10(12):3513.
  2. Komiya H, Takeuchi H, Ogawa Y, Suzuki K, Ogasawara A, Takahashi K, Azuma YT, Doi H, Tanaka F. Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis. Molecular Brain 14(1):74.
  3. 小野尚重，東　泰孝．IL-19の抗炎症作用を活かした治療への応用．日本薬理学雑誌 156(5):288-291.
  4. Horiuchi H, Parajuli B, Komiya H, Ogawa Y, Jin S, Takahashi K, Azuma YT, Tanaka F, Suzumura A, Takeuchi H. Interleukin-19 abrogates experimental autoimmune encephalomyelitis by attenuating antigen-presenting cell activation. Front. Immunol. 12:615898.
  5. Azuma YT, Suzuki S, Nishiyama K, Yamaguchi T. Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel. J. Vet. Med. Sci. 83(4):622-629.
  6. Fujimoto Y, Kuramoto N, Yoneyama M, Azuma YT. Interleukin-19 as an immunoregulatory cytokine. Curr. Mol. Pharmacol. 14(2):191-199.
　2020　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Fujimoto Y, Kuwamura M, Azuma YT. Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-induced acute liver failure. J. Vet. Med. Sci. 82(10):1450-1455.
  2. Gütschow M, Vanden Eynde JJ, Jampílek J, Kang CB, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, Muñoz-Torrero D. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7. Molecules 25(13):2968.
  3. Azuma YT, Nishiyama K. Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice. J. Vet. Med. Sci. 82(7):891-896.
  4. Natsume C, Aoki N, Aoyama T, Senda K, Matsui M, Ikegami A, Tanaka K, Azuma YT, Fujita T. Fucoxanthin ameliorates atopic dermatitis symptoms by regulating keratinocytes and regulatory innate lymphoid cells. Int. J. Mol. Sci. 21(6): 2180.
  5. Vanden Eynde JJ, Mangoni AA, Rautio J, Leprince J, Azuma YT, García-Sosa AT, Hulme C, Jampilek J, Karaman R, Li W, Gomes PAC, Hadjipavlou-Litina D, Capasso R, Geronikaki A, Cerchia L, Sabatier JM, Ragno R, Tuccinardi T, Trabocchi A, Winum JY, Luque FJ, Prokai-Tatrai K, Spetea M, Gütschow M, Kosalec I, Guillou C, Vasconcelos MH, Kokotos G, Rastelli G, de Sousa ME, Manera C, Gemma S, Mangani S, Siciliano C, Galdiero S, Liu H, Scott PJH, de Los Ríos C, Agrofoglio LA, Collina S, Guedes RC, Muñoz-Torrero D. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6. Molecules 25(1): 119.
　2019　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Fujimoto Y, Aono K, Azuma YT. The clarified role of interleukin-19 in the inflammatory bowel disease and hypersensitivity: insights from animal models and humans. J. Vet. Med. Sci. 81(8):1067-1073.
  2. Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M. Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complex. Br. J. Pharmacol. 176(18): 3723-3738.
  3. Aono K, Azuma YT, Nabetani T, Hatoya S, Furuya M, Miki M, Hirota K, Fujimoto Y, Nishiyama K, Ogata Y, Mochizuki T, Tani H. Correlation between toll-like receptor 4 and nucleotide-binding oligomerization domain 2 (NOD2) and pathological severity in dogs with chronic gastrointestinal diseases. Vet. Immunol. Immunopathol. 210: 15-22.
  4. Nishiyama K, Aono K, Fujimoto Y, Kuwamura M, Okada T, Tokumoto H, Izawa T, Okano R, Nakajima H, Takeuchi T, Azuma YT. Chronic kidney disease following 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility. J. Cell. Physiol. 234(5): 6667-6678.
  5. 藤本泰之，東　泰孝．多臓器に着目したインターロイキン-19による新規炎症調節機能．日本薬理学雑誌 154(2):66-71.
　2018　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Nishiyama K, Fujimoto Y, Takeuchi T, Azuma YT. Aggressive crosstalk between fatty acids and inflammation in macrophages and their influence on metabolic homeostasis. Neurochem. Res. 43(1): 10-17.
  2. Nishimura Y, Moriyama M, Kawabe K, Satoh H, Takano K, Azuma YT, Nakamura Y. Lauric acid alleviates neuroinflammatory responses by activated microglia: involvement of the GPR40-dependent pathway. Neurochem. Res. 43(9): 1723-1735.
  3. Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT. The Role of Interleukin-19 in Contact Hypersensitivity. Biol. Pharma. Bull. 41(2): 182-189.
  4. Nishiyama K, Fujita T, Fujimoto Y, Nakajima H, Takeuchi T, Azuma YT. Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling. Int. Immunopharmacol. 55: 205-215.
　2017　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. World J. Cardiol. 9(8): 673-684.
  2. 西山和宏，藤本泰之，竹内正吉，東　泰孝．代謝性疾患における脂肪酸とマクロファージによる炎症応答とのクロストーク．日本薬理学雑誌 149(5):200-203.
  3. Fujimoto Y, Azuma YT, Matsuo Y,Kuwamura M, Kuramoto N, Miki M, Azuma N, Teramoto M, Nishiyama K, Izawa T, Nakajima H, Takeuchi T. Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis. Naunyn Schmiedebergs Arch. Pharmacol. 390(3): 261-268.
  4. Nishiyama K, Tanioka K, Azuma YT, Hayashi S, Fujimoto Y, Yoshida N, Kita S, Suzuki S, Nakajima H, Iwamoto T, Takeuchi T. Na+/Ca2+ exchanger contribute to stool transport in mice with experimental diarrhea. J. Vet. Med. Sci. 79(2): 403-411.
　2016　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Fujimoto Y, Hayashi S, Azuma YT, Mukai K, Nishiyama K, Kita S, Morioka A, Nakajima H, Iwamoto T, Takeuchi T. Overexpression of Na+/Ca2+ exchanger 1 display enhanced relaxation in the gastric fundus. J. Pharmacol. Sci. 132(3): 181-186.
  2. Nishiyama K, Azuma YT, Morioka A, Yoshida N, Teramoto M, Tanioka K, Kita S, Hayashi S, Nakajima H, Iwamoto T, Takeuchi T. Roles of Na+/Ca2+ exchanger isoforms NCX1 and NCX2 in motility in mouse ileum. Naunyn Schmiedeberg Arch. Pharmacol. 389(10): 1081-1090.
  3. Azuma YT, Hayashi S, Nishiyama K, Kita S, Mukai K, Nakajima H, Iwamoto T, Takeuchi T. Na+/Ca2+ exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo. Neurogastroenterol. Motil. 28(6): 827-836.
  4. Azuma YT, Samezawa N, Nishiyama K, Nakajima H, Takeuchi T. Differences in time to peak carbachol-induced contractions between circular and longitudinal smooth muscles of mouse ileum. Naunyn Schmiedeberg Arch. Pharmacol. 389(1): 63-72.
　2015　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Matsuo Y, Azuma YT, Kuwamura M, Kuramoto N, Nishiyama K, Yoshida N, Ikeda Y, Fujimoto Y, Nakajima H, Takeuchi T. Interleukin 19 reduces inflammation in chemically induced experimental colitis. Int. Immunopharmacol. 29(2): 468-475.
  2. Horiuchi H, Parajuli B, Wang Y, Azuma YT, Mizuno T, Takeuchi H, Suzumura A. Interleukin-19 acts as a negative autocrine regulator of activated microglia. PLoS One 10(3):e0118640.
　2014　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Nishiyama K, Morioka A, Kita S, Nakajima H, Iwamoto T, Azuma YT, Takeuchi T. Na+/Ca2+ exchanger 1 transgenic mice display increased relaxation in the distal colon. Pharmacology 94(5-6), 230-238.
  2. Nishiyama K, Azuma YT, Shintaku K, Yoshida N, Nakajima H, Takeuchi T. Evidence that nitric oxide is a nonadrenergic-noncholinergic inhibitory neurotransmitter in the circular muscle of mouse distal colon: study on the mechanism of nitric oxide-induced relaxation. Pharmacology 94(3-4), 99-108.
  3. Ellison S, Gabunia K, Richards J, Kelemen S, Miecyjak A, England RN, Rudic D, Azuma YT, Eguchi S, Autieri MV. Interleukin-19 reduces Ligation-Mediated Neointimal Hyperplasia by Reducing VSMC Activation. Am. J. Pathol. 184(7), 2134-2143.
  4. 東　泰孝、竹内正吉. インターロイキン-19による腸免疫制御システムの調節－炎症性腸疾患モデルマウスからの知見. 日本薬理学雑誌　143(6), 275-278.
　2013　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Nishiyama K, Azuma YT, Kita S, Azuma N, Hayashi S, Nakajima H, Iwamoto T, Takeuchi T. Na+/Ca2+ exchanger 1/2 double-heterozygote knockout mice display increased nitric oxide component and altered colonic motility. J. Pharmacol. Sci. 123(3), 235-245.
　2012　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Azuma YT, Nishiyama K, Kita S, Komuro I, Nakajima H, Iwamoto T, Takeuchi T. Na+/Ca2+ exchanger 2-heterozygote knockout mice display decreased acetylcholine release and altered colonic motility in vivo. Neurogastroenterol. Motil. 24(12), e600-e610.
  2. Fujimoto Y, Nakatani N, Kubo T, Semi Y, Yoshida N, Nakajima H, Iseri T, Azuma YT, Takeuchi T. Adenosine and ATP affect LPS-induced cytokine production in canine macrophage cell line DH82 cells. J. Vet. Med. Sci. 74(1), 27-34.
　2011　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Azuma YT, Nakajima H, Takeuchi T. IL-19 as a Potential Therapeutic in Autoimmune and Inflammatory Diseases. Curr. Pharma. Des. 17(34), 3776-3780.
  2. Azuma YT, Nishiyama K, Morioka A, Nakajima H, Takeuchi T. Clofibrate Relaxes the Longitudinal Smooth Muscle of the Mouse Distal Colon through Calcium-mediated Desensitisation of Contractile Machinery. Pharmacology 88(1-2), 65-71.
  3. Azuma YT, Matsuo Y, Nakajima H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Takeuchi T. Interleukin-19 is a Negative Regulator of Innate Immunity and Critical for Colonic Protection. J. Pharmacol. Sci. 115(2), 105-111.
　2010　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Azuma YT, Nishiyama K, Matsuo Y, Kuwamura M, Morioka A, Nakajima H, Takeuchi T. PPARa contributes to colonic protection in mice with DSS-induced colitis. Int. Immunopharmacol. 10(10), 1261-1267.
  2. Azuma YT, Matsuo Y, Kuwamura M, Yancopoulos GD, Valenzuela DM, Murphy AJ, Nakajima H, Karow M, Takeuchi T. Interleukin-19 protects mice from innate-mediated colonic inflammation. Inflamm. Bowel Dis. 16(6), 1017-1028.
  3. Hidaka A, Azuma YT, Nakajima H, Takeuchi T. Nitric oxide and carbon monoxide act as inhibitory neurotransmitters in the longitudinal muscle of C57BL/6J mouse distal colon. J. Pharmacol. Sci. 112(2), 231-241.
　2009　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. 東　泰孝，竹内正吉. 下部消化管炎症と消化管ペプチド．日本薬理学雑誌 133(4): 199-202.
　2008　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  1. Takeuchi T, Yamashiro N, Kawasaki T, Nakajima H, Azuma YT, Matsui M. The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse. Neuroscience 156(2), 381-389.
  2. Hagi K, Azuma YT, Nakajima H, Shintani N, Hashimoto H, Baba A, Takeuchi T. Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus. Eur. J. Pharmacol. 590(1-3), 80-86.
  3. Azuma YT, Hagi K, Shintani N, Kuwamura M, Nakajima H, Hashimoto H, Baba A, Takeuchi T. PACAP provides colonic protection against dextran sodium sulfate induced colitis. J. Cell. Physiol. 216(1), 111-119.
　2007　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
    1. Takeuchi T, Nakajima H, Hata F, Azuma YT. A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon. Pflugers Arch. 454, 565-574.
    2. Takeuchi T, Tanaka K, Nakajima H, Matsui M, Azuma YT. M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: finding obtained from muscarinic receptor knockout mouse. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G154-164.
    　2006　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
    1. Tran EH, Azuma YT, Chen M, Weston C, Davis RJ, Flavell RA. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proc. Natl. Acad. Sci. USA. 103, 13451-13456.
    2. Satoh Y, Okishio Y, Azuma YT, Nakajima H, Hata F, Takeuchi T. Orexin A affects ascending contration depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum. Neuropharmacology 51, 466-473.
    3. Takeuchi T, Nakamura A, Nakajima H, Azuma YT, Hata F. Inhibitory effects of alendronate on cholinergic responses in rat lower esophageal sphincter. Eur. J. Pharmacol. 537, 155-159.
    4. Takeuchi T, Toyoshima M, Mukai K, Hagi K, Matsui M, Nakajima H, Azuma YT, Hata F. Involvement of M2 muscarinic receptors in relaxant response of circular muscle of mouse gastric antrum. Neurogastroenterol. Motil. 18, 226-233.
    　2005　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
    1. Schulz O, Diebold SS, Chen M, Naslund TI, Nolte MA, Alexopoulou L, Azuma YT, Flavell RA, Liljestrom P, Reis e Sousa C. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433(7028), 887-892.