Department of Medical Biochemistry,
Graduate School of Medicine,
Osaka Metropolitan University

Vice Dean, Professor Fuminori Tokunaga

We study on protein ubiquitination in health and diseases.

Our research interests are:

・Cellular and physiological roles of linear ubiquitination-mediated NF-κB activation

・TNF-α- and ROS-induced cell death pathways

・Development of inhibitors for linear ubiquitin code

・Functional analysis of deubiquitinating enzymes

・Functional and structural analyses of ubiquitin-binding proteins

・Protein ubiquitination and aggregation in neurodegenerative diseases such as amyotrophic lateral sclerosis and Alzheimer’s disease

・Regulators in innate and acquired immune responses and their related diseases