Hoshino K, Nakazawa S, Yokobori T, Hagiwara K, Ishii N, Tsukagoshi M, Igarashi T, Araki K, Harimoto N, Tokunaga F, Shirabe K. RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation. Sci. Rep. 14(1), 346, (2023).
Yanagawa H, Hara Y, Ando F, Suzuki S, Fujiki T, Oikawa D, Yui N, Mandai S, Mori Y, Susa K, Mori T, Sohara E, Tokunaga F, Uchida S. LRBA signalosomes activate vasopressin-induced AQP2 trafficking at recycling endosomes. J. Physiol. 601(23), 5437-5451, (2023).
Fukushi M, Ohsawa R, Okinaka Y, Oikawa D, Kiyono T, Moriwaki M, Irie T, Oda K, Kamei Y, Tokunaga F, Sotomaru Y, Maruyama H, Kawakami H, Sakaguchi T. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection PLoS One18(6):e0287545, (2023).
Oikawa D, Shimizu K,Tokunaga F. Pleiotropic roles of a KEAP1-associated deubiquitinase, OTUD1. Antioxidants 12(2), 350, (2023).
Sato Y, Terawaki S, Oikawa D, Shimizu K, Okina Y, Ito H,Tokunaga F. Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis. Front. Mol. Biosci. 10, 1089213, (2023).
2022年
Saito R, Tada Y, Oikawa D, Sato Y, Seto M, Satoh A, Kume K, Ueki N, Nakashima M, Hayashi S, Toyoshima Y,Tokunaga F, Kawakami H, Kakita A. Spinocerebellar ataxia type 17-digenic TBP/STUB1 disease: neuropathologic features of an autopsied patient. Acta. Neuropathol. Commun.10(1), 177, (2022).
Nakazawa S, Mamiya R, Kawabata-Iwakawa R, Oikawa D, Kaira K, Tokunaga F, Nobusawa S, Sato Y, Sasaki A, Yajima T, Shirabe K. Identification and molecular analysis of RNF31 Q622H germline polymorphism. Oncol. Lett, 24(5),394, (2022).
Oikawa D, Gi M, Kosako H, Shimizu K, Takahashi H, Shiota M, Hosomi S, Komakura K, Wanibuchi H, Tsuruta D, Sawasaki T, Tokunaga F. OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways. Cell Death Dis., 13,694, (2022).
Zhang Q, Terawaki S, Oikawa D, Okina Y, Usuki Y, Ito H, Tokunaga F. Suppression of linear ubiquitination ameliorates cytoplasmic aggregation of truncated TDP-43. Cells, 11, 2398, (2022).
Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika, H, Tokunaga F, Uchida S. LRBA is essential for urinary concentration and body water homeostasis. Proc. Natl. Acad. Sci. USA, 119, e2202125119, (2022).
Yoshizato K, Taira T, Sato-Matsubara M, Sekiguchi S, Yabunaka Y, Kira Y, Ohashi T, Daikoku A, Ofusa K, Kadono C, Oikawa D, Matsubara T, Nakagama Y, Kido Y, Tokunaga F, Ikeda K, Kaneko A, Kawada N. Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry. J. Biochem. 172(4), 205-216, (2022).
Hoang DV, Thuy LTT, Hai H, Hieu VN, Kimura K, Oikawa D, Ikura Y, Dat NQ, Hoang TH, Sato-Matsubara M, Dong MP, Hanh NV, Uchida-Kobayashi S, Tokunaga F, Kubo S, Ohtani N, Yoshizato K, Kawada N. Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species. Oncogenesis, 11, 23, (2022)
Tokunaga F, Ikeda F. Linear ubiquitination in immune and neurodegenerative diseases, and beyond. Biochem. Soc. Trans., 50(2), 799-811, (2022)
Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Shiro Y, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, Kawada N. Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion. Redox Biol., 52, 102286, (2022)
2021年
Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Motegi SI, Tokunaga F, Ishikawa O. Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease. Sci. Rep., 11, 23146, (2021)
Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F. Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. Inflamm. Res., 70, 539-541, (2021)
Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F. Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. PLoS One, 16, e0248158, (2021)
Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H. Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Cell Rep., 37(6), 109988, (2021)
Miyashita H+, Oikawa D+(+ equally contributed), Terawaki S, Kabata D, Shintani A, Tokunaga F. Crosstalk between NDP52 and LUBAC in innate immune responses, cell death, and xenophagy. Front. Immunol., 12, 635475, (2021)
Dat NQ, Thuy LTT, Hieu VN, Hai H, Hoang DV, Thi Thanh Hai N, Thuy TTV, Komiya T, Rombouts K, Dong MP, Hanh NV, Hoang TH, Sato-Matsubara M, Daikoku A, Kadono C, Oikawa D, Yoshizato K, Tokunaga F, Pinzani M, Kawada N. 6His-tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species. Hepatology, 73(6), 2527-2545, (2021)
Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O. The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis. J. Am. Acad. Dermatol., 84, 1103-1105, (2021)
Nakabayashi O, Takahashi H, Moriwaki K, Komazawa-Sakon S, Ohtake F, Murai S, Tsuchiya Y, Koyahara Y, Saeki Y, Yoshida Y, Yamazaki S, Tokunaga F, Sawasaki T, Nakano H. MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL. Commun. Biol., 4(1), 80, (2021)
Oikawa D, Hatanaka N, Suzuki T, Tokunaga F. Cellular and mathematical analyses of LUBAC involvement in T cell receptor-mediated NF-κB activation pathway. Front. Immunol.,11, 601926, (2020)
Okina Y, Matsubara-Sato M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thuy Le TT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N. TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. J. Hepatol., 73, 882-895, (2020)
Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, Sawasaki T. A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors. Biomedicines 8, 152, (2020)
Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O. The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis. J. Am. Acad. Dermatol. S0190-9622 (20)30916-6, (2020)
Oikawa D, Sato Y, Ito H, Tokunaga F. Linear ubiquitin code: Its writer, erasers, decoders, inhibitors, and implications in disorders. Int. J. Mol. Sci.21, 3381, (2020)
Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F. Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses. Commun. Biol. 3, 163, (2020)
Nakayama Y, Tsuji K, Ayaki T, Mori M, Tokunaga F, Ito H. Linear polyubiquitin chain modification of TDP-43-Positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 79, 256-265, (2020)
Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunaga F., Takahashi H., Sawasaki T. Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling. Biochem Biophys Res Commun. 524, 1-7, (2020)
Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T. The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. J. Biol. Chem. 294, 14135-14138, (2019)
Nakayama Y, Sakamoto S, Tsuji K, Ayaki T, Tokunaga F, Ito H. Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer's disease. Neurosci. Lett.703, 53-57, (2019)
Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem. Biophys. Res. Commun. 509(3), 700-706, (2019)
Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F. Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1.Monoclon Antib Immunodiagn Immunother. 37(4):180-184 (2018).
Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M. High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System. SLAS Discov. 2:2472555218793066 (2018).
Oikawa D, Shiota M, Tokunaga F, Wanibuchi H. Generation of rat monoclonal antibodies specific for DZIP3. Monoclon. Antib. Immunodiagn. Immunother.37(3)157-157 (2018)
Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki SI, Wakamatsu K, Tokunaga F, Shimizu A. In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.J. Dermatol. Sci. 91(1) 35-42 (2018)
Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A. Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency. J. Dermatol. 45(5), e108-e109 (2018)
Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, and Inoue JI. HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. PLoS Pathogens. 13, e100162 (2017)
Hattori M, Shimizu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O. Endoplasmic reticulum stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa. Br. J. Dermatol. 177(4), e92-e93 (2017)
Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H. Reduced SHARPIN and LUBAC formation may contribute to CCl₄- or acetaminophen-induced liver cirrhosis in mice. Int. J. Mol. Sci. 18(2), 326 (2017)
Goto E and Tokunaga F. Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP. Biochem. Biophys. Res. Commun. 485(1), 152-159 (2017)
2016
Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, and Nureki O: Structural and functional analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Sci. Rep. 6, 34756 (2016).
Nakazawa S, Oikawa D, Ishi R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F: Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. (2016) Nat. Commun. 7, 12547.
Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, and Yamaoka S: A20 targets caspase-8 and FADD to protect HTLV-I infected cells. (2016) Leukemia, 30, 716-727.
2015
Kumanomidou T, Nishio K, Takagi K, Nakagawa T, Suzuki A, Yamane T, Tokunaga F, Iwai K, Murakami A, Yoshida Y, Tanaka K, and Mizushima T: The Structural Differences between a Glycoprotein Specific F-box Protein Fbs1 and its Homologous Protein FBG3. (2015) PLoS One, 10, e0140366.
Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, and Asano T: 13. LUBAC formation is impaired in the livers of mice with MCD-dependent nonalcoholic steatohepatitis. (2015) Mediators Inflamm., 125380.
Sato Y, Goto E, Shibata Y, Kubota Y, Yamagata A, Goto-Ito S, Kubota K, Inoue J, Takekawa M, Tokunaga F, and Fukai S: Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity. (2015) Nat. Struct. Mol. Biol., 22, 222-229.
Kato M, Shimizu A, Yokoyama Y, Kaira K, Shimomura Y, Ishida-Yamamoto A, Kamei K, Tokunaga F, and Ishikawa O: A novel autosomal recessive mutation of DSG4 causes monilethrix through the ER stress response. (2015) Invest. Dermatol., 135, 1253-1260.
Naguro I, Umeda T, Kobayashi Y, Maruyama J, Hattori K, Shimizu Y, Kataoka K, Kim-Mitsuyama S, Uchida S, Vandewalle A, Noguchi T, Nishitoh H, Matsuzawa A, Takeda K, Ichijo H: ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.(2012) Nat Commun., 3, 1285.
Fuminori Tokunaga*, Hiroshi Nishimasu*, Ryuichiro Ishitani, Eiji Goto, Takuya Noguchi, Kazuhiro Mio, Kiyoko Kamei, Averil Ma, Kazuhiro Iwai, and Osamu Nureki: Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation. (2012) EMBO J. 31 (19), 3856-3870, (*; equal contribution).
Fuminori Tokunaga and Kazuhiro Iwai: Linear ubiquitination: A novel NF-kB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex. (2012) Endocrine J., 59 (8), 641-652.
Tobias Kensche*, Fuminori Tokunaga*, Fumiyo Ikeda, Eiji Goto, Kazuhiro Iwai, and Ivan Dikic: Analysis of NF-κB essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. (2012) J. Biol. Chem., 287 (28), 23626-23634, (*; equal contribution).
Fuminori Tokunaga and Kazuhiro Iwai: LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses. (2012) Microbes Infect., 14 (7-8), 563-572.
Yoshinori Uekusa, Syunsuke Miura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Oliver, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, and Koichi Kato; Backbone and side chain 1H, 13C, and 15N assignments of ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Biomol. NMR Assign., 6 (2), 177-180 (2012)
Masato Tomonaga, Nobuyuki Hashimoto, Fuminori Tokunaga, Megumi Onishi, Akira Myoui, Hideki Yoshikawa, and Kazuhiro Iwai; Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells. (2012)Int. J. Oncol. 40 (2), 409-417.
Mizuho Kajikawa, Pai-Chi Li, Eiji Goto, Naoyuki Miyashita, Masami Aoki-Kawasumi, Mari Mito-Yoshida, Mika Ikegaya, Yuji Sugita, and Satoshi Ishido; The intramembrane region of Kaposi’s sarcoma-associated Herpesvirus modulator of immune recognition 2 contributes to B7-2 downregulation. (2012) J. Virol. 86 (9), 5286-5296.
Hidetaka Tanno, Teppei Yamaguchi, Eiji Goto, Satoshi Ishido, and Masayuki Komada; The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. (2012) Mol. Biol. Cell 23 (7), 1343-1353.
Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki, Masami Taniguchi, Shin-ichi Sakata, Keiji Tanaka, Hiroyasu Nakano, and Kazuhiro Iwai; Sharpin is a component of the NF-κB activating linear ubiquitin assembly complex. (2011) Nature, 471, 633-641. [http://www.ncbi.nlm.nih.gov/pubmed/21455180
Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skånland, Benjamin Stieglitz, Caroline Grabbe, Sjoerd van WijK, Mirita Franz-Wachtel, Panchali Goswami, Vanja Nagy, Janos Terzic, Fuminori Tokunaga, Ariadne Androulidaki, Tomoko Nakagawa, Manolis Pasparakis, Kazuhiro Iwai, John P. Sundberg, Liliana Schaefer, Boris Macek, Katrin Rittinger, and Ivan Dikic; SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. (2011) Nature, 471, 637-641. [http://www.ncbi.nlm.nih.gov/pubmed/21455181
Kyung-Soo Inn, Michaela U. Gack, Fuminori Tokunaga, Mude Shi, Lai-Yee Wong, Kazuhiro Iwai, and Jae U. Jung; Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction. (2011) Mol. Cell, 41, 354-365. [http://www.ncbi.nlm.nih.gov/pubmed/21292167