メンバー紹介(永井 正義)

助教:永井 正義

Assistant Professor: Masayoshi Nagai

nagai(at)omu.ac.jp

自己紹介

直鎖ユビキチンを起点とし、細胞から個体まで一貫した研究ができるよう、日々精進しています。

趣味は麻雀で、振るのが大得意です。

略歴

山口県下関市出身。静岡大学理学部生物科学科卒業、静岡大学大学院理学研究科修士課程修了、富士市立高等学校常勤講師を経て、東北大学大学院医学系研究科博士課程修了(田中耕三教授)。

福岡大学先端分子医学研究所ポスト・ドクター、九州大学大学院農学研究院特任助教、ミシガン大学医学部Postdoctoral Research Fellowを経て2024年4月より現職。

 researchmap

主な研究業績

  1. Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioural phenotype. Nagai M, Iemura K, Kikkawa T, Naher S, Hattori S, Hagihara H, Nagata KI, Anzawa H, Kugisaki R, Wanibuchi H, Abe T, Inoue K, Kinoshita K, Miyakawa T, Osumi N, Tanaka K. Brain Commun. 2022 Aug 30;4(5):fcac220.
  2. TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells. Yamada C, Morooka A, Miyazaki S, Nagai M, Mase S, Iemura K, Tasnin MN, Takuma T, Nakamura S, Morshed S, Koike N, Mostofa MG, Rahman MA, Sharmin T, Katsuta H, Ohara K, Tanaka K, Ushimaru T. iScience. 2021 Dec 27;25(2):103675.
  3. Growth Suppression of Cancer Spheroids With Mutated KRAS by Low-toxicity Compounds from Natural Products. Hashimoto S, Nagai M, Nishi K, Ishikura S, Nakabayashi K, Yazaki R, Ohshima T, Suenaga M, Shirasawa S, Tsunoda T. Anticancer Res. 2021 Aug;41(8):4061-4070.
  4. The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes. Ishikura S, Nagai M, Tsunoda T, Nishi K, Tanaka Y, Koyanagi M, Shirasawa S. J Cell Biochem. 2021 Jun;122(6):626-638.
  5. ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis. Ishikura S, Nakabayashi K, Nagai M, Tsunoda T, Shirasawa S. Nucleic Acids Res. 2020 Nov 4;48(19):10848-10866.
  6. Cdh1 degradation is mediated by APC/C-Cdh1 and SCF-Cdc4 in budding yeast. Nagai M, Shibata A, Ushimaru T. Biochem Biophys Res Commun. 2018 Dec 2;506(4):932-938.
  7. CDK phosphorylation regulates Mcm3 degradation in budding yeast. Yamamoto K, Makino N, Nagai M, Araki H, Ushimaru T. Biochem Biophys Res Commun. 2018 Nov 30;506(3):680-684.
  8. TORC1 signaling regulates DNA replication via DNA replication protein levels. Yamamoto K, Makino N, Nagai M, Honma Y, Araki H, Ushimaru T. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1128-1133.
  9. Elucidation of novel budding yeast separase mutants. Shimizu Y, Nagai M, Yeasmin AM, Koike N, Talukdar MW, Ushimaru T. Biosci Biotechnol Biochem. 2016;80(3):473-478.
  10. Cdh1 is an antagonist of the spindle assembly checkpoint. Nagai M, Ushimaru T. Cell Signal. 2014 Oct;26(10):2217-2222.