メンバー紹介（清水 康平）

講師：清水 康平

Lecturer : Kouhei Shimizu

shimizu.kouhei(at)omu.ac.jp

自己紹介
略歴
主な研究業績

自己紹介

疾患発症の分子メカニズムに興味があります。

いつか新しい現象の発見から創薬につながる仕事ができればと思っています。

週末はバスケットボールで体を動かして、サウナと銭湯でリフレッシュしています。

略歴

愛媛県松山市出身。2013年9月、愛媛大学大学院理工学研究科博士課程修了（澤崎達也教授）。

ハーバード大学医学部BIDMCポスドク、東北大学大学院歯学研究科助教を経て2019年10月より現職。

researchmap

主な研究業績

  1. The interplay between cell death and senescence in cancer. Shimizu K, Inuzuka H, Tokunaga F. Semin Cancer Biol. 2024 Nov 16:S1044-579X(24)00085-3.
  2. Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1. Oikawa D, Shimizu K, Tokunaga F. Antioxidants (Basel). 2023 Feb 1;12(2):350.
  3. Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis. Sato Y, Terawaki S, Oikawa D, Shimizu K, Okina Y, Ito H, Tokunaga F. Front Mol Biosci. 2023 Jan 16;10:1089213.
  4. OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways. Oikawa D, Gi M, Kosako H, Shimizu K, Takahashi H, Shiota M, Hosomi S, Komakura K, Wanibuchi H, Tsuruta D, Sawasaki T, Tokunaga F. Cell Death Dis. 2022 Aug 8;13(8):694.
  5. Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H. Cell Rep. 2021;37(6):109988.
  6. Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer. Dang F, Nie L, Zhou J, Shimizu K, Chu C, Wu Z, Fassl A, Ke S, Wang Y, Zhang J, Zhang T, Tu Z, Inuzuka H, Sicinski P, Bass AJ, Wei W. Nat Commun. 2021;12(1):5386.
  7. Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F. Inflamm Res. 2021;70(5):539-541.
  8. Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F. PLoS One. 2021 Mar 4;16(3):e0248158.
  9. Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation. Hoshikawa S, Shimizu K, Watahiki A, Chiba M, Saito K, Wei W, Fukumoto S, Inuzuka H. FASEB J. 2020;34(11):14930-14945.
  10. Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H. Biochem Biophys Res Commun. 2020;524(2):477-483.
  11. The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T. J Biol Chem. 2019;294(38):14135-14148.
  12. Physiological functions of FBW7 in cancer and metabolism. Shimizu K, Nihira NT, Inuzuka H, Wei W. Cell Signal. 2018;46:15-22.
  13. NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis. Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H. Mol Cell. 2017;68(4):645-658.
  14. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W. Nat Med. 2017;23(9):1063-1071.
  15. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W. Sci Signal. 2017;10(466):eaai8026.
  16. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kołodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P. Nat Cell Biol. 2017;19(3):177-188.
  17. The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W. Sci Signal. 2017;10(460):eaah4117.
  18. Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression. Nagashima K, Fukushima H, Shimizu K, Yamada A, Hidaka M, Hasumi H, Ikebe T, Fukumoto S, Okabe K, Inuzuka H. Oncotarget. 2017;8(6):9947-9960.
  19. The apoptotic initiator caspase-8: its functional ubiquity and genetic diversity during animal evolution. Sakamaki K, Shimizu K, Iwata H, Imai K, Satou Y, Funayama N, Nozaki M, Yajima M, Nishimura O, Higuchi M, Chiba K, Yoshimoto M, Kimura H, Gracey AY, Shimizu T, Tomii K, Gotoh O, Akasaka K, Sawasaki T, Miller DJ. Mol Biol Evol. 2014;31(12):3282-301.
  20. Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion. Shimizu K, Uematsu A, Imai Y, Sawasaki T. FEBS Lett. 2014;588(17):3030-7.
  21. Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity. Shimizu K, Sawasaki T. FEBS Lett. 2013;587(14):2219-25.
  22. Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3. Shimizu K, Takahama S, Endo Y, Sawasaki T. PLoS One. 2012;7(8):e42721.
  23. Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling. Akagi T, Shimizu K, Takahama S, Iwasaki T, Sakamaki K, Endo Y, Sawasaki T. FEBS Lett. 2011;585(12):1835-40.
  24. Characterization of a caspase-3-substrate kinome using an N- and C-terminally tagged protein kinase library produced by a cell-free system. Tadokoro D, Takahama S, Shimizu K, Hayashi S, Endo Y, Sawasaki T. Cell Death Dis. 2010;1(10):e89.
  25. Biotinylated-sortase self-cleavage purification (BISOP) method for cell-free produced proteins. Matsunaga S, Matsuoka K, Shimizu K, Endo Y, Sawasaki T. BMC Biotechnol. 2010;10:42.